NHR48_CAEEL
ID NHR48_CAEEL Reviewed; 817 AA.
AC Q94407; Q9BJL1; Q9BJL2;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 3.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Nuclear hormone receptor family member nhr-48;
GN Name=nhr-48; ORFNames=ZK662.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), AND NUCLEOTIDE SEQUENCE [MRNA] OF
RP 248-817 (ISOFORM B).
RX PubMed=15983867; DOI=10.1007/s00239-004-0175-8;
RA Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.;
RT "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4
RT in nematodes.";
RL J. Mol. Evol. 60:577-586(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Orphan nuclear receptor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=Q94407-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q94407-2; Sequence=VSP_020165, VSP_020166, VSP_020167;
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
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DR EMBL; AF332204; AAK17975.1; -; mRNA.
DR EMBL; AF332205; AAK17976.1; -; mRNA.
DR EMBL; Z79604; CAB01900.1; -; Genomic_DNA.
DR EMBL; Z79604; CAD36502.1; -; Genomic_DNA.
DR PIR; T27941; T27941.
DR RefSeq; NP_001024998.1; NM_001029827.3.
DR RefSeq; NP_001024999.1; NM_001029828.2.
DR AlphaFoldDB; Q94407; -.
DR SMR; Q94407; -.
DR BioGRID; 46553; 1.
DR DIP; DIP-24311N; -.
DR IntAct; Q94407; 1.
DR STRING; 6239.ZK662.3b; -.
DR EPD; Q94407; -.
DR PaxDb; Q94407; -.
DR PeptideAtlas; Q94407; -.
DR EnsemblMetazoa; ZK662.3a.1; ZK662.3a.1; WBGene00003638.
DR EnsemblMetazoa; ZK662.3b.1; ZK662.3b.1; WBGene00003638.
DR UCSC; ZK662.3b; c. elegans. [Q94407-1]
DR WormBase; ZK662.3a; CE18456; WBGene00003638; nhr-48. [Q94407-2]
DR WormBase; ZK662.3b; CE31141; WBGene00003638; nhr-48. [Q94407-1]
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00940000171624; -.
DR InParanoid; Q94407; -.
DR OMA; SCSTAME; -.
DR OrthoDB; 297114at2759; -.
DR Reactome; R-CEL-159418; Recycling of bile acids and salts.
DR Reactome; R-CEL-196791; Vitamin D (calciferol) metabolism.
DR Reactome; R-CEL-4090294; SUMOylation of intracellular receptors.
DR PRO; PR:Q94407; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00003638; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR ExpressionAtlas; Q94407; baseline.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00399; ZnF_C4; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus; Receptor;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..817
FT /note="Nuclear hormone receptor family member nhr-48"
FT /id="PRO_0000053784"
FT DNA_BIND 97..172
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 100..120
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 136..155
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 49..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 258..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 163
FT /note="V -> VSLAEKSHRLEELFV (in isoform b)"
FT /evidence="ECO:0000303|PubMed:15983867"
FT /id="VSP_020165"
FT VAR_SEQ 269
FT /note="G -> GYSNHDF (in isoform b)"
FT /evidence="ECO:0000303|PubMed:15983867"
FT /id="VSP_020166"
FT VAR_SEQ 292..348
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000303|PubMed:15983867"
FT /id="VSP_020167"
SQ SEQUENCE 817 AA; 90706 MW; 036211C94A913BB9 CRC64;
MYNTRRSAYM NSCSTAMELP PQSLHQNWQD TEYVNTTCSS DMNSDMSMYN DDKDDPFYED
EGSGGGTSGG GKKSSRKRAN TTSSSGGNEK ESKRTANKVC RVCGDKAFSY NFNVITCESC
KAFFRRNANK EKEIRCPFNE QCEINMVSRR FCQRCRLTKC FAVGMKKEWI MSEEARLEKK
QRVEENRERR LQDAMNRALE EACMEDESEN SYDEAPAPSH QMSVRQYLAN DDAPHKSSDE
VQPHLGHHGY NQKEDKMMNF YQDGPSDQGD YSLPSNSCAS SSQLDTSVNC GATTIADNGA
SPSNTVTIPA AVDVERKPIP TNVLFSASMS AIQDVAAIIS NAETKNLGMC APDVVNENLM
NVAQAAVQAQ AIVNHTQQLA AAVVAQQVVS NMAPVMPTVN PLDPLLAPAF IAPPMPTPIN
VPITTPIAGA LSTPLPPPIV PPGHSSINPV IPIIPKEMPV SVSLLNQLEQ TPAEMVTVPK
DMLMKLIQKN SRSTCTCSCM CGRYPPGSCI VDEVTKDLLN GGSSNSSNAT DRDETRLETT
EDMQMNGLLP GDCNSSIQWL NQQSSAQAFV DPITHSMTAE EAQTQRERRD SIFGSFSAAD
QGTVTQPKSV QEETIWEHTV AENESRELSD EEIEKMEELT EISNQWISMR LDSMPILDLF
SKKNVEKIVN GLKLLSSFRF LPQVDKRSVV KRGLFNYCVV KWMQHKESMS IDGLSDAARR
DFMNIIRREE FNYRVQPGAF NTLAISVLFH SISDNLISTD VYMEHLVFKK LLDKNLPIKV
SSDTVYNNYY PYIIKAAKHL EKATKGLSDE LVAHAVS
