ID   NHR4_CAEEL              Reviewed;         492 AA.
AC   O45436;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 2.
DT   03-AUG-2022, entry version 159.
DE   RecName: Full=Nuclear hormone receptor family member nhr-4;
GN   Name=nhr-4; ORFNames=F32B6.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Bristol N2;
RX   PubMed=10022975;
RA   Sluder A.E., Mathews S.W., Hough D., Yin V.P., Maina C.V.;
RT   "The nuclear receptor superfamily has undergone extensive proliferation and
RT   diversification in nematodes.";
RL   Genome Res. 9:103-120(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Orphan nuclear receptor.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
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DR   EMBL; AF083223; AAD03681.1; -; mRNA.
DR   EMBL; Z81074; CAB03044.2; -; Genomic_DNA.
DR   PIR; T21645; T21645.
DR   PIR; T43346; T43346.
DR   RefSeq; NP_501775.1; NM_069374.8.
DR   AlphaFoldDB; O45436; -.
DR   BioGRID; 42943; 9.
DR   DIP; DIP-25524N; -.
DR   IntAct; O45436; 9.
DR   STRING; 6239.F32B6.1; -.
DR   EPD; O45436; -.
DR   PaxDb; O45436; -.
DR   EnsemblMetazoa; F32B6.1.1; F32B6.1.1; WBGene00003603.
DR   GeneID; 177839; -.
DR   KEGG; cel:CELE_F32B6.1; -.
DR   UCSC; F32B6.1.2; c. elegans.
DR   CTD; 177839; -.
DR   WormBase; F32B6.1; CE24934; WBGene00003603; nhr-4.
DR   eggNOG; KOG3575; Eukaryota.
DR   HOGENOM; CLU_007368_3_3_1; -.
DR   InParanoid; O45436; -.
DR   OMA; DVAFGKH; -.
DR   OrthoDB; 622732at2759; -.
DR   PhylomeDB; O45436; -.
DR   SignaLink; O45436; -.
DR   PRO; PR:O45436; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00003603; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..492
FT                   /note="Nuclear hormone receptor family member nhr-4"
FT                   /id="PRO_0000053758"
FT   DOMAIN          215..481
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        47..122
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         50..70
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         86..110
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          121..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   492 AA;  55465 MW;  CB191A1112225F22 CRC64;
     MNERGMLVDP RFDAFFKLEQ IDDYKYDGAD TSPSTSNGLP ETSNGGRLIC DVCGDVAFGK
     HYGINACNGC KGFFRRSVWS RRQYSCRFGG DCPVVKEHRN VCRSCRLKKC FEVGMNPDSV
     QNERDRNAKN GGMGGPMSSP TQSSLCKELT ISNGQIKRKR LRPETVEKTT QTDGKLEIND
     DFDFENMQQN PTPPGLLPLK IERISTPPSD LPVPMDFSIH SAVLDIEQKV FYNCPVAVDN
     SINATKTPIT LPFEVVFRQP HLVCNRYPMR FSNTRVLTPE DLIDGWRRHF TYYSDWCHAM
     DEFKALSPED QIVLAKKKII LHGWLVHAYY SYKSGCNGIC FANGAAHLPE GGHPSITEFY
     KECMPRYLNY VIYPMHNFQM DDAEMVLIKC IMFFSSESGL SAAGRQIVSA AREKYLSALY
     NYGRANKCTT SAQATLRIAK FMIMLSAITS LTHLMNEGVH VTSLFNIIEF DELIQATHKT
     TPPQHSPPAP MG