ID   NHR52_CAEEL             Reviewed;         338 AA.
AC   O17928;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Nuclear hormone receptor family member nhr-52;
GN   Name=nhr-52; ORFNames=K06B4.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15983867; DOI=10.1007/s00239-004-0175-8;
RA   Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.;
RT   "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4
RT   in nematodes.";
RL   J. Mol. Evol. 60:577-586(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Orphan nuclear receptor.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF273797; AAG15146.1; -; Transcribed_RNA.
DR   EMBL; Z83233; CAB05761.1; -; Genomic_DNA.
DR   PIR; T23365; T23365.
DR   RefSeq; NP_506899.1; NM_074498.1.
DR   AlphaFoldDB; O17928; -.
DR   SMR; O17928; -.
DR   STRING; 6239.K06B4.2; -.
DR   PaxDb; O17928; -.
DR   PRIDE; O17928; -.
DR   EnsemblMetazoa; K06B4.2.1; K06B4.2.1; WBGene00003642.
DR   GeneID; 3565623; -.
DR   KEGG; cel:CELE_K06B4.2; -.
DR   UCSC; K06B4.2; c. elegans.
DR   CTD; 3565623; -.
DR   WormBase; K06B4.2; CE11784; WBGene00003642; nhr-52.
DR   eggNOG; KOG3575; Eukaryota.
DR   GeneTree; ENSGT00970000195839; -.
DR   HOGENOM; CLU_007368_3_0_1; -.
DR   InParanoid; O17928; -.
DR   OMA; INRILCQ; -.
DR   OrthoDB; 8912at6231; -.
DR   PhylomeDB; O17928; -.
DR   PRO; PR:O17928; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00003642; Expressed in pharyngeal muscle cell (C elegans).
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..338
FT                   /note="Nuclear hormone receptor family member nhr-52"
FT                   /id="PRO_0000053786"
FT   DOMAIN          98..337
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        1..75
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         3..23
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         39..63
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ   SEQUENCE   338 AA;  39582 MW;  2C6F27E986176E89 CRC64;
     MKCLVCCSYA SSRNFGALSC SACKMFFTRA TKNYAKFTCK YDKKCFESFT ILPKCQFCRF
     KKCLEIGMRF SEPKQQLFNL NNSVDQDLII LLGNLAVKDG VHYSNFLNFY SLEDPSMDDI
     LADRSRMKLM KRTLEIKTKS HEWTFLGSYY KIAQFLDFDF VKTMSLADRK ILFSYNTLRM
     GSLSRSMRTY LDKRDCLMTP SGDDLFSPAV RGLFDKTPEI INRILCQVVG RLMEIKITYE
     EYLLLIMIVF CNPSISHELS DSARETLSKY QNMYASFLFR FCQLKNQHKA PTRFNDILSI
     CNVNNKNVED YCFVHMMFQC MVPEFKFKKL VNDIIIRS