NHR53_CAEEL
ID NHR53_CAEEL Reviewed; 364 AA.
AC O17933; Q9GTG0; Q9GTG1;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 31-JAN-2002, sequence version 3.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Nuclear hormone receptor family member nhr-53;
GN Name=nhr-53; ORFNames=K06B4.11;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15983867; DOI=10.1007/s00239-004-0175-8;
RA Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.;
RT "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4
RT in nematodes.";
RL J. Mol. Evol. 60:577-586(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Orphan nuclear receptor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG15147.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAG15148.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF273798; AAG15147.1; ALT_INIT; mRNA.
DR EMBL; AF273799; AAG15148.1; ALT_INIT; mRNA.
DR EMBL; Z83233; CAB05768.2; -; Genomic_DNA.
DR PIR; T23372; T23372.
DR RefSeq; NP_741644.1; NM_171556.4.
DR AlphaFoldDB; O17933; -.
DR SMR; O17933; -.
DR BioGRID; 45046; 7.
DR IntAct; O17933; 3.
DR STRING; 6239.K06B4.11; -.
DR PaxDb; O17933; -.
DR PRIDE; O17933; -.
DR EnsemblMetazoa; K06B4.11.1; K06B4.11.1; WBGene00003643.
DR GeneID; 180053; -.
DR KEGG; cel:CELE_K06B4.11; -.
DR UCSC; K06B4.11; c. elegans.
DR CTD; 180053; -.
DR WormBase; K06B4.11; CE27770; WBGene00003643; nhr-53.
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00970000196534; -.
DR HOGENOM; CLU_007368_1_1_1; -.
DR InParanoid; O17933; -.
DR OMA; FLCEAFP; -.
DR OrthoDB; 998503at2759; -.
DR PhylomeDB; O17933; -.
DR PRO; PR:O17933; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00003643; Expressed in embryo and 2 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..364
FT /note="Nuclear hormone receptor family member nhr-53"
FT /id="PRO_0000053787"
FT DOMAIN 110..363
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 20..95
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 23..43
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 59..83
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ SEQUENCE 364 AA; 41980 MW; 6E6016AAA5AC9F2E CRC64;
MPSPTHLLNN FESSSSQGPP SYCLICCEVA DGHHFGAAAC RACAAFFRRT VQLNKVHDCP
KNGQCFILSN VRNMCRACRY EKCLEVGMQR SSVQQKRDQL GRRDGLPTNR EEPVLDTMRR
AYEKLLVVRK KVHNRQENQL PRAISFNELQ VVYQNEMTVI YQFLCEAFPE YSELLPDTKR
SLFKNFFLPF TLLESSYYGY LTKQENVMLI PSGDYVDLAH LESYFNNNHH TFSQKDTISM
FAQQFRMLHT SITVPLSAEN VDVNEFLALA AIILWESDLE VEADRKNVQE EAVKIKSAII
KDLLFHYQSI NVYADVAMRL GAVLSILPSI QRASHRFHEY MEIKNLLNLY ALPKNLYDMF
SPTS
