ID   NHR54_CAEEL             Reviewed;         422 AA.
AC   O45460; Q9GTF9;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=Nuclear hormone receptor family member nhr-54;
GN   Name=nhr-54; ORFNames=F36D3.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 151-422.
RX   PubMed=15983867; DOI=10.1007/s00239-004-0175-8;
RA   Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.;
RT   "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4
RT   in nematodes.";
RL   J. Mol. Evol. 60:577-586(2005).
CC   -!- FUNCTION: Orphan nuclear receptor.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
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DR   EMBL; Z81531; CAB04316.1; -; Genomic_DNA.
DR   EMBL; AF273800; AAG15149.1; -; mRNA.
DR   PIR; T21850; T21850.
DR   RefSeq; NP_507179.3; NM_074778.4.
DR   AlphaFoldDB; O45460; -.
DR   SMR; O45460; -.
DR   STRING; 6239.F36D3.2; -.
DR   PaxDb; O45460; -.
DR   PRIDE; O45460; -.
DR   EnsemblMetazoa; F36D3.2.1; F36D3.2.1; WBGene00003644.
DR   GeneID; 180106; -.
DR   KEGG; cel:CELE_F36D3.2; -.
DR   UCSC; F36D3.2; c. elegans.
DR   CTD; 180106; -.
DR   WormBase; F36D3.2; CE15966; WBGene00003644; nhr-54.
DR   eggNOG; KOG3575; Eukaryota.
DR   GeneTree; ENSGT00970000195937; -.
DR   HOGENOM; CLU_007368_7_0_1; -.
DR   InParanoid; O45460; -.
DR   OMA; VIFSERC; -.
DR   OrthoDB; 1136195at2759; -.
DR   PhylomeDB; O45460; -.
DR   PRO; PR:O45460; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00003644; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..422
FT                   /note="Nuclear hormone receptor family member nhr-54"
FT                   /id="PRO_0000053788"
FT   DOMAIN          161..422
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        14..92
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         17..37
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         53..80
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ   SEQUENCE   422 AA;  49473 MW;  3B652E904C86C9AC CRC64;
     MEIPSTSSEM TYFSVKCAIC YKAGHGQHFG VETCRACAAF FRRTVVLNRK YKCTRKSGKC
     KIGSDETKDV MCKFCRFKKC IDLGMTTENV RTDQVINLNV EPSTSQSLVR LEMTSLQPET
     DDSNRVQYQI IHPRTRGPAI LIDVNAIIKR SKTILETHFF PDDDVIVELN PLEKMTFCLR
     KLRSKQSWNP NFFTKINFLD LFEFWESQME DTATWLMYSG EFRKLPNHEK IAIFKIVWAV
     WRRLERYTMT AQVFGQKCYD EQILLHSHQD AARFTDYDVD YSYITDQGFE KINGLFGGKM
     IQYFDIIVKP YLELELSDTE IAYILCQIVW NYAGRRLQGQ TQAAGERFLE VISNNLHKYY
     EDKSGNRKRA EDKQNYVARL AKMMQIVNQM LNAQLKMENT MDVAMLFNTF NIVFTEPEFF
     RV