NHR55_CAEEL
ID NHR55_CAEEL Reviewed; 424 AA.
AC O16962; Q86PK7; Q9GTF7; Q9GTF8;
DT 16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 2.
DT 25-MAY-2022, entry version 145.
DE RecName: Full=Nuclear hormone receptor family member nhr-55;
GN Name=nhr-55; ORFNames=T01G6.7;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15983867; DOI=10.1007/s00239-004-0175-8;
RA Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.;
RT "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4
RT in nematodes.";
RL J. Mol. Evol. 60:577-586(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Orphan nuclear receptor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
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DR EMBL; AY204171; AAO39175.1; -; mRNA.
DR EMBL; AF273801; AAG15150.1; -; mRNA.
DR EMBL; AF273802; AAG15151.1; -; mRNA.
DR EMBL; FO081653; CCD73122.1; -; Genomic_DNA.
DR PIR; T32189; T32189.
DR RefSeq; NP_503215.2; NM_070814.4.
DR AlphaFoldDB; O16962; -.
DR STRING; 6239.T01G6.7; -.
DR PaxDb; O16962; -.
DR PRIDE; O16962; -.
DR EnsemblMetazoa; T01G6.7.1; T01G6.7.1; WBGene00003645.
DR GeneID; 178570; -.
DR KEGG; cel:CELE_T01G6.7; -.
DR UCSC; T01G6.7; c. elegans.
DR CTD; 178570; -.
DR WormBase; T01G6.7; CE37786; WBGene00003645; nhr-55.
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00940000164378; -.
DR HOGENOM; CLU_007368_7_1_1; -.
DR InParanoid; O16962; -.
DR OMA; MPQYSMR; -.
DR OrthoDB; 997001at2759; -.
DR PhylomeDB; O16962; -.
DR PRO; PR:O16962; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00003645; Expressed in material anatomical entity and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..424
FT /note="Nuclear hormone receptor family member nhr-55"
FT /id="PRO_0000053789"
FT DOMAIN 169..424
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 25..100
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 28..55
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 64..88
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 424 AA; 49241 MW; CD09E3C41E6E4CB4 CRC64;
MNSPSSSSSF CSSSSSPSSL VLYSPDTCQV CGQKSHGKHF GAVTCRACAA FFRRCGSANN
FKPCRRNMNC EFLKNGWFNC KPCRLKKCQD VGMTIENFQF DRDSFSPKKA KIALENFHNQ
VPFSIATFTG RSNLIVISAP TEEECIPKCY IDVQFLIDKL SNVLKEGPEV PLHTPNALEK
LALGLQIIRG RKRELKLITK LGKEETLGLW QDDMMKVAKW LTYFDDFQQL SHRMRSEMLK
GMWKVWSRLE TLALTAMGRR LMICQKDMIM THTEKEQVMA HPKQIEVDIS WCSRYTLEQL
RFFADSDLDD RNEQVIQAMM ELQPTDVELS YMMCQACLHY AGKRYQGEVL EIAERFQETL
SNHLHDYYVN RMNMPQYSMR VANLMKINNH IQLDIYRGRV KYDLARVFDV FYLEFSHPEV
FIDL