ID   NHR57_CAEEL             Reviewed;         374 AA.
AC   O16425;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 142.
DE   RecName: Full=Nuclear hormone receptor family member nhr-57;
GN   Name=nhr-57; ORFNames=T05B4.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Orphan nuclear receptor.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
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DR   EMBL; FO081330; CCD70827.1; -; Genomic_DNA.
DR   PIR; T31842; T31842.
DR   RefSeq; NP_504153.1; NM_071752.5.
DR   AlphaFoldDB; O16425; -.
DR   SMR; O16425; -.
DR   STRING; 6239.T05B4.2; -.
DR   PaxDb; O16425; -.
DR   EnsemblMetazoa; T05B4.2.1; T05B4.2.1; WBGene00003647.
DR   GeneID; 178813; -.
DR   KEGG; cel:CELE_T05B4.2; -.
DR   UCSC; T05B4.2; c. elegans.
DR   CTD; 178813; -.
DR   WormBase; T05B4.2; CE13195; WBGene00003647; nhr-57.
DR   eggNOG; KOG3575; Eukaryota.
DR   HOGENOM; CLU_007368_1_1_1; -.
DR   InParanoid; O16425; -.
DR   OMA; SRDSCKS; -.
DR   OrthoDB; 865404at2759; -.
DR   PhylomeDB; O16425; -.
DR   PRO; PR:O16425; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00003647; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045087; P:innate immune response; HEP:WormBase.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0001666; P:response to hypoxia; IMP:WormBase.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..374
FT                   /note="Nuclear hormone receptor family member nhr-57"
FT                   /id="PRO_0000223578"
FT   DOMAIN          124..374
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        7..84
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         10..30
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         48..67
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ   SEQUENCE   374 AA;  42932 MW;  89B785CC2B1B94EB CRC64;
     MLVARERKYC SVCHQLGDGY HFGAIACKAC AAFFRRTTSM NLAPKFVCRK KNECVIKMSS
     RDSCKSCRYA KCLHVGMNPE VVQAIQQAAK QANSPGIESL PSCSSSPASC NSPILSLELG
     DYDQMTPTLC GVMESYQKLY KKRYDLHAPK LTPRATNYGE FCKIYSNDVY LQFEFLEGSF
     PQFKEMGGFE KKHVFKYFFV SFLILEMGYR SYQEGTDAIV LANGDFIDTM NLDEFYYDPE
     SLEKCKPTDA MKMYRPNFDQ MKRNVFQPLS HQKLSLIEFL ALVSLCTWNE SLDGQPDCYY
     PSCRPVRQSV IADLKAFYEK DSPDVDPAYR LSGLLMLLPA LERSVELFLQ TMEVKRLFRC
     FPFHDKIYKI IDGQ