ID   NHR59_CAEEL             Reviewed;         416 AA.
AC   Q9TXJ1; Q9GTF2;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2001, sequence version 2.
DT   03-AUG-2022, entry version 143.
DE   RecName: Full=Nuclear hormone receptor family member nhr-59;
GN   Name=nhr-59 {ECO:0000312|WormBase:T27B7.1a};
GN   ORFNames=T27B7.1 {ECO:0000312|WormBase:T27B7.1a};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15983867; DOI=10.1007/s00239-004-0175-8;
RA   Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.;
RT   "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4
RT   in nematodes.";
RL   J. Mol. Evol. 60:577-586(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Orphan nuclear receptor.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
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DR   EMBL; AF273807; AAG15156.1; -; mRNA.
DR   EMBL; FO081753; CCD74242.1; -; Genomic_DNA.
DR   RefSeq; NP_503624.2; NM_071223.5.
DR   AlphaFoldDB; Q9TXJ1; -.
DR   STRING; 6239.T27B7.1; -.
DR   EPD; Q9TXJ1; -.
DR   PaxDb; Q9TXJ1; -.
DR   EnsemblMetazoa; T27B7.1a.1; T27B7.1a.1; WBGene00003649.
DR   GeneID; 178707; -.
DR   KEGG; cel:CELE_T27B7.1; -.
DR   UCSC; T27B7.1; c. elegans.
DR   CTD; 178707; -.
DR   WormBase; T27B7.1a; CE30194; WBGene00003649; nhr-59.
DR   eggNOG; KOG3575; Eukaryota.
DR   GeneTree; ENSGT00940000164378; -.
DR   HOGENOM; CLU_007368_7_1_1; -.
DR   InParanoid; Q9TXJ1; -.
DR   OMA; IILARNC; -.
DR   OrthoDB; 1136195at2759; -.
DR   PhylomeDB; Q9TXJ1; -.
DR   PRO; PR:Q9TXJ1; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00003649; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   ExpressionAtlas; Q9TXJ1; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..416
FT                   /note="Nuclear hormone receptor family member nhr-59"
FT                   /id="PRO_0000053790"
FT   DOMAIN          162..415
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        17..94
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         20..40
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         57..82
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ   SEQUENCE   416 AA;  47721 MW;  D4A21CA587ED96D3 CRC64;
     MHPDSSRKLA LKAVVNQTFC QVCGQESHGA HFGAITCRAC AAFFRRVAAG ANFEVKCKDG
     RGRCKILTNG RSCCKKCRLK KCKDIGMDIQ NFQFNRDSFA TSTKVAPSLS TFLGRPEFLL
     SCSPGTSAST SQNKFIDLSP FIKNCKQVLM DDRKIPLAPG KTRLQKLSSS LDFEISANNK
     KKKTDLRKVS TLGFSEAIQI FENELLMTSK WLAHFEEFHD LGNDFKFKFL ECTWNIWNRL
     ERVARTAALL RDQKISNGKG NEIILARNCV IDLRTVKFEV EWFTNYSLSE ISYFIEGVGD
     WSMNKPLQAI IDFNPTEIEL NFMLAQISLT CASKQMDSQY QETIDNLQKL IADDLHSYYI
     KEMRLPVYSS RIQKMMKVNN MVLRVMWERK EKLSIARMFN IFNPNFSHPE LVKDVF