ID   NHR5_CAEEL              Reviewed;         672 AA.
AC   Q9NA51;
DT   30-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2012, sequence version 2.
DT   03-AUG-2022, entry version 154.
DE   RecName: Full=Nuclear hormone receptor family member nhr-5;
GN   Name=nhr-5; ORFNames=Y73F8A.21;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=10022975;
RA   Sluder A.E., Mathews S.W., Hough D., Yin V.P., Maina C.V.;
RT   "The nuclear receptor superfamily has undergone extensive proliferation and
RT   diversification in nematodes.";
RL   Genome Res. 9:103-120(1999).
CC   -!- FUNCTION: Orphan nuclear receptor.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
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DR   EMBL; AL132862; CAB60549.2; -; Genomic_DNA.
DR   RefSeq; NP_502856.2; NM_070455.2.
DR   AlphaFoldDB; Q9NA51; -.
DR   SMR; Q9NA51; -.
DR   BioGRID; 56213; 22.
DR   IntAct; Q9NA51; 21.
DR   STRING; 6239.Y73F8A.21a; -.
DR   PaxDb; Q9NA51; -.
DR   PRIDE; Q9NA51; -.
DR   EnsemblMetazoa; Y73F8A.21a.1; Y73F8A.21a.1; WBGene00003604.
DR   GeneID; 191717; -.
DR   UCSC; Y73F8A.21; c. elegans.
DR   CTD; 191717; -.
DR   WormBase; Y73F8A.21a; CE46694; WBGene00003604; nhr-5.
DR   eggNOG; KOG3575; Eukaryota.
DR   GeneTree; ENSGT00940000153391; -.
DR   HOGENOM; CLU_420495_0_0_1; -.
DR   InParanoid; Q9NA51; -.
DR   PhylomeDB; Q9NA51; -.
DR   PRO; PR:Q9NA51; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00003604; Expressed in larva and 3 other tissues.
DR   ExpressionAtlas; Q9NA51; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..672
FT                   /note="Nuclear hormone receptor family member nhr-5"
FT                   /id="PRO_0000053759"
FT   DOMAIN          155..424
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        40..115
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         43..63
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         79..98
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          550..577
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..23
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   672 AA;  75298 MW;  8B7F5E8E9C9979CA CRC64;
     MSSGGNSSNV NRNSGSSNVI TLNDSDEETE DSNLGSSSST NLCKVCGAEK AALHYGALSC
     VGCKGFFRRA LLKADQLECA ANGECTVSVL QKTQCRSCRF NKCLREGMNP AYVRPNRDAP
     PKPRKPTTTV ATCDQTDRGR TTKSREEWMK KMTVEMRTIL MTLLNIETKV MKGDTQQEAS
     KLYPLKGIDK LSDIIETPIQ LKGKRTEMRY EAYRMAGNDE LCAIAYRRLI AAIDWVESLS
     PLLGHLTPQD KIALVKSSFA PLMVFNFCAR TAEACQDENV LCLCNFAYVP RNISKMYEDT
     YHLGNGLVER ALNELVAVYR EYGMREEEIV CVNAMICLNP LAKDVSDSLF EKIVELRNRI
     ADCLFSIVKE VRLSPTPNVC YGHILLSLAT VTELANAMSE NLQFAQTFSN QGEIPLLTDL
     FGCFTVEPFF KEVDELAAMS LEKAKAEKKK EMSTQTDRLP PPRALLKRQA TIDEDSEEPA
     RQNFRLLQPP NNFYITEMLD DLRNNHAENH LISLNFDASN VSNAIASRPS FEDLGTVPSG
     STVTRRIGSN IQGPSHLPQC GSTVTQRPTV PSSTTSSTFY NFPPPPGYPP LNAGYTPNVN
     YPNLYQQPQY FQNFQQNNYP SQVMEQQNYG NVESTSYPFP RNDGFVYNHP NIPYSHHNNS
     LQQNNFHNQY AN