NHR61_CAEEL
ID NHR61_CAEEL Reviewed; 412 AA.
AC O62389; Q9U355;
DT 16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 2.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Nuclear hormone receptor family member nhr-61;
GN Name=nhr-61; ORFNames=W01D2.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Orphan nuclear receptor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=O62389-1; Sequence=Displayed;
CC Name=b;
CC IsoId=O62389-2; Sequence=VSP_007123;
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
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DR EMBL; Z83128; CAB05636.1; -; Genomic_DNA.
DR EMBL; Z83128; CAB05637.1; -; Genomic_DNA.
DR PIR; T26056; T26056.
DR PIR; T26057; T26057.
DR RefSeq; NP_001022381.1; NM_001027210.4. [O62389-1]
DR RefSeq; NP_001022382.1; NM_001027211.4. [O62389-2]
DR AlphaFoldDB; O62389; -.
DR SMR; O62389; -.
DR BioGRID; 40423; 2.
DR DIP; DIP-24810N; -.
DR IntAct; O62389; 2.
DR STRING; 6239.W01D2.2b.1; -.
DR EPD; O62389; -.
DR PaxDb; O62389; -.
DR EnsemblMetazoa; W01D2.2a.1; W01D2.2a.1; WBGene00003651. [O62389-1]
DR EnsemblMetazoa; W01D2.2b.1; W01D2.2b.1; WBGene00003651. [O62389-2]
DR GeneID; 175142; -.
DR KEGG; cel:CELE_W01D2.2; -.
DR UCSC; W01D2.2a; c. elegans. [O62389-1]
DR CTD; 175142; -.
DR WormBase; W01D2.2a; CE20124; WBGene00003651; nhr-61. [O62389-1]
DR WormBase; W01D2.2b; CE20125; WBGene00003651; nhr-61. [O62389-2]
DR eggNOG; KOG3575; Eukaryota.
DR HOGENOM; CLU_007368_3_3_1; -.
DR InParanoid; O62389; -.
DR OMA; WLCSTWS; -.
DR OrthoDB; 882366at2759; -.
DR PhylomeDB; O62389; -.
DR PRO; PR:O62389; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00003651; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR ExpressionAtlas; O62389; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus; Receptor;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..412
FT /note="Nuclear hormone receptor family member nhr-61"
FT /id="PRO_0000053791"
FT DOMAIN 144..407
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 27..102
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 30..50
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 66..90
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 287
FT /note="I -> IEYV (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_007123"
SQ SEQUENCE 412 AA; 46541 MW; B884385113521255 CRC64;
MIVDSISSST ASTSSSSPTR GTPIRKSLQC AVCGDVALGK HYGVNACNGC KGFFRRSIWK
NRTYACRHGG KCLVAKEQRN ACRSCRLTRC LDVGMNPRAV QGDTVEDPEW DEEAMPETLS
ISTQTDALKV KKKSHTSLFT LDIKKEQIID NLRAIYARTD PEEFWKLTYP GTYDFRYAFH
NTKVVSPRTP LTPTAERIAT LNDVVADFRR AFVLFVDILK SIDQLRDVQE DDKMKIAKSR
FAAFYWWLCS TWSAKAGCNG VCYSNGSYHP ASISDMPKSE GKHGVRIDYS GVSQKSLENL
VEPLRRMELS DEERIVGAVM VILADPVPNV STKTEKILAE ARDFYLELLG YCIKLPEEQQ
GIRVSTMVLL LASIMELVHL TTDNIQLSDV LHVIDLGDWS QELRDHRYRR QF
