NHR62_CAEEL
ID NHR62_CAEEL Reviewed; 515 AA.
AC O02279; B3WFY6;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 3.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Nuclear hormone receptor family member nhr-62;
GN Name=nhr-62; ORFNames=Y67A6A.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Orphan nuclear receptor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=O02279-1; Sequence=Displayed;
CC Name=b;
CC IsoId=O02279-2; Sequence=VSP_053632;
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
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DR EMBL; AL032645; CAA21675.2; -; Genomic_DNA.
DR EMBL; Z83235; CAA21675.2; JOINED; Genomic_DNA.
DR EMBL; Z83235; CAQ76486.1; -; Genomic_DNA.
DR PIR; T23558; T23558.
DR RefSeq; NP_001129799.1; NM_001136327.2. [O02279-2]
DR RefSeq; NP_492607.1; NM_060206.6. [O02279-1]
DR AlphaFoldDB; O02279; -.
DR SMR; O02279; -.
DR BioGRID; 38259; 9.
DR IntAct; O02279; 9.
DR STRING; 6239.Y67A6A.2a; -.
DR EPD; O02279; -.
DR PaxDb; O02279; -.
DR PeptideAtlas; O02279; -.
DR PRIDE; O02279; -.
DR EnsemblMetazoa; Y67A6A.2a.1; Y67A6A.2a.1; WBGene00003652. [O02279-1]
DR EnsemblMetazoa; Y67A6A.2b.1; Y67A6A.2b.1; WBGene00003652. [O02279-2]
DR GeneID; 172836; -.
DR KEGG; cel:CELE_Y67A6A.2; -.
DR UCSC; Y67A6A.2; c. elegans. [O02279-1]
DR CTD; 172836; -.
DR WormBase; Y67A6A.2a; CE27305; WBGene00003652; nhr-62. [O02279-1]
DR WormBase; Y67A6A.2b; CE42745; WBGene00003652; nhr-62. [O02279-2]
DR eggNOG; KOG3575; Eukaryota.
DR HOGENOM; CLU_007368_3_3_1; -.
DR InParanoid; O02279; -.
DR OMA; CAIAKEH; -.
DR OrthoDB; 622732at2759; -.
DR PhylomeDB; O02279; -.
DR SignaLink; O02279; -.
DR PRO; PR:O02279; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00003652; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR ExpressionAtlas; O02279; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus; Receptor;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..515
FT /note="Nuclear hormone receptor family member nhr-62"
FT /id="PRO_0000223579"
FT DOMAIN 225..509
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 95..170
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 98..118
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 134..158
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 169..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..194
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..162
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_053632"
SQ SEQUENCE 515 AA; 58070 MW; 51052519E69EFFF5 CRC64;
MFSTLSPSAI DDILRHAVHF GQGTTAIAPS PVTFISTTTQ QSLGATYPGV FNPTTPTFNH
YQHQALPVTM HTSTSSAHHT TTGHGRGRRK NSTINLVCVV CGDQAFGKHY GVNACNGCKG
FFRRSVWHNR QYLCRFEGRC AIAKEHRNVC RACRLKQCFV AGMNPRAVQS ERVEREQNGS
PNQIEEDDYK DLSSPDTCSV EIQTDVDEQK PSSNNSAPLP SMELEMAKLS EQIVEMHRAV
CSYVDPVTKR ENFDMKMETE TTKIAFMNAF YNPEMIGPRT PLDITGRRVA TVKDVMDEWK
RNFVLFSDWL RALPEYNQMS IEDQIVLAKN RYGTFHWWMC ANWTVQAGCE GVCYSNGAYF
PKQPEAQCIP DVKGSSGRMY DSLSIPIKEL NLDETEIVLM LAVIIFSDEI TELADLTPAG
KEHVRMVGNR FVRMLHHHVN SKEYGEAMEN GDDTQNSSES QAAVRIAKMM ILLSATTNLV
YLTSDNIQLM EVLHVVPSEY LCHEVQFIQN SYETP
