NHR64_CAEEL
ID NHR64_CAEEL Reviewed; 369 AA.
AC O44960; D4YW56; D4YW57; Q688B5; Q86PK4; Q86PK5; Q86PK6;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 2.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=Nuclear hormone receptor family member nhr-64;
GN Name=nhr-64; ORFNames=C45E1.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
RX PubMed=15983867; DOI=10.1007/s00239-004-0175-8;
RA Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.;
RT "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4
RT in nematodes.";
RL J. Mol. Evol. 60:577-586(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Orphan nuclear receptor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=O44960-1; Sequence=Displayed;
CC Name=b;
CC IsoId=O44960-2; Sequence=VSP_015669;
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
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DR EMBL; AY204172; AAO39176.1; -; mRNA.
DR EMBL; AY204173; AAO39177.1; -; mRNA.
DR EMBL; AY204174; AAO39178.1; -; mRNA.
DR EMBL; FO080867; CCD67352.1; -; Genomic_DNA.
DR EMBL; FO080867; CCD67353.1; -; Genomic_DNA.
DR PIR; T32890; T32890.
DR RefSeq; NP_001021042.2; NM_001025871.3. [O44960-1]
DR RefSeq; NP_001021043.2; NM_001025872.4. [O44960-2]
DR AlphaFoldDB; O44960; -.
DR SMR; O44960; -.
DR BioGRID; 37361; 2.
DR DIP; DIP-26511N; -.
DR IntAct; O44960; 1.
DR STRING; 6239.C45E1.1a; -.
DR SwissLipids; SLP:000000578; -.
DR EPD; O44960; -.
DR PaxDb; O44960; -.
DR PeptideAtlas; O44960; -.
DR EnsemblMetazoa; C45E1.1a.1; C45E1.1a.1; WBGene00003654. [O44960-1]
DR EnsemblMetazoa; C45E1.1a.2; C45E1.1a.2; WBGene00003654. [O44960-1]
DR EnsemblMetazoa; C45E1.1b.1; C45E1.1b.1; WBGene00003654. [O44960-2]
DR GeneID; 171884; -.
DR UCSC; C45E1.1b; c. elegans. [O44960-1]
DR CTD; 171884; -.
DR WormBase; C45E1.1a; CE39696; WBGene00003654; nhr-64. [O44960-1]
DR WormBase; C45E1.1b; CE39697; WBGene00003654; nhr-64. [O44960-2]
DR eggNOG; KOG4215; Eukaryota.
DR HOGENOM; CLU_007368_5_2_1; -.
DR InParanoid; O44960; -.
DR OMA; EEATCDQ; -.
DR OrthoDB; 622732at2759; -.
DR PhylomeDB; O44960; -.
DR SignaLink; O44960; -.
DR PRO; PR:O44960; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00003654; Expressed in larva and 3 other tissues.
DR ExpressionAtlas; O44960; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR GO; GO:0003707; F:nuclear steroid receptor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR000003; Retinoid-X_rcpt/HNF4.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00545; RETINOIDXR.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus; Receptor;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..369
FT /note="Nuclear hormone receptor family member nhr-64"
FT /id="PRO_0000053792"
FT DOMAIN 120..352
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 67..142
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 70..90
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 106..130
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT VAR_SEQ 49..73
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000303|PubMed:15983867"
FT /id="VSP_015669"
SQ SEQUENCE 369 AA; 41838 MW; 492D12EE85CEFD7E CRC64;
MTLEEKEEVS TSTSQSPQSS SFENVFCAIC GDRATGKHYG AMSCDGCKGF FRRTIRKRHS
YVCRFGEKCQ VDKAKRNSCR KCRFDVCLRK GMRRDAVQTE RDRIRPANPL SNGSNGGIVP
DDPLLDTLIR AEASTRGLRT TVITKTAEAR KQATTNDVTD SMNQQLTLMV EWAKVLEGFQ
RVDNITQVAL LRHFSAQHLV MCAAFRSIHL SDAVWLTNET CLHKDSPKIP DMNRVAERII
DQVTNPMRSL HMNEIEYIAL KAIAFFDPLA KGITSESYSD VEEMRQRILE SFERHVRYVS
PYKDMPLRFA NLLLLLPPML AISRDLVEDV QLAKLFGLAS IDNLMLELML PNEGKNTTDK
TSPPIMCHQ
