ID   NHR65_CAEEL             Reviewed;         401 AA.
AC   O45907; Q7YTK0; Q9GTE3;
DT   16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 149.
DE   RecName: Full=Nuclear hormone receptor family member nhr-65;
GN   Name=nhr-65; ORFNames=Y17D7A.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 128-401 (ISOFORM A).
RX   PubMed=15983867; DOI=10.1007/s00239-004-0175-8;
RA   Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.;
RT   "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4
RT   in nematodes.";
RL   J. Mol. Evol. 60:577-586(2005).
CC   -!- FUNCTION: Orphan nuclear receptor.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=a;
CC         IsoId=O45907-1; Sequence=Displayed;
CC       Name=b;
CC         IsoId=O45907-2; Sequence=VSP_009635;
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
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DR   EMBL; AL021470; CAA16292.1; -; Genomic_DNA.
DR   EMBL; AL021470; CAE17952.1; -; Genomic_DNA.
DR   EMBL; AF273816; AAG15165.1; -; mRNA.
DR   PIR; T26479; T26479.
DR   RefSeq; NP_001024219.1; NM_001029048.4. [O45907-1]
DR   RefSeq; NP_001024220.1; NM_001029049.3. [O45907-2]
DR   AlphaFoldDB; O45907; -.
DR   STRING; 6239.Y17D7A.3a; -.
DR   EPD; O45907; -.
DR   PaxDb; O45907; -.
DR   EnsemblMetazoa; Y17D7A.3a.1; Y17D7A.3a.1; WBGene00003655. [O45907-1]
DR   EnsemblMetazoa; Y17D7A.3b.1; Y17D7A.3b.1; WBGene00003655. [O45907-2]
DR   GeneID; 180230; -.
DR   KEGG; cel:CELE_Y17D7A.3; -.
DR   UCSC; Y17D7A.3a; c. elegans. [O45907-1]
DR   CTD; 180230; -.
DR   WormBase; Y17D7A.3a; CE16588; WBGene00003655; nhr-65. [O45907-1]
DR   WormBase; Y17D7A.3b; CE35061; WBGene00003655; nhr-65. [O45907-2]
DR   eggNOG; KOG3575; Eukaryota.
DR   GeneTree; ENSGT00970000196183; -.
DR   InParanoid; O45907; -.
DR   OMA; HQNEFAV; -.
DR   OrthoDB; 1676394at2759; -.
DR   PhylomeDB; O45907; -.
DR   PRO; PR:O45907; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00003655; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; DNA-binding; Metal-binding; Nucleus; Receptor;
KW   Reference proteome; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..401
FT                   /note="Nuclear hormone receptor family member nhr-65"
FT                   /id="PRO_0000053793"
FT   DOMAIN          132..398
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        10..79
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         13..33
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         49..67
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   VAR_SEQ         367..401
FT                   /note="VDMLKMRQRQEISRVFDIWTIDFSHPEFIQDANAC -> ESVLKTRQRQQIA
FT                   ELFNVWTVDFSHPEFFRDA (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_009635"
SQ   SEQUENCE   401 AA;  46799 MW;  1D5B60B38CC6EBF2 CRC64;
     MELEPCSSSP ERCKVCGDTG NGMHFGAFTC RACAAFFRRA ASRKFLRKCE NHLIFALKCK
     NCRLQRCYEA GMSSENFQFC RDLIGAKGAI PKLKVPKSFE QTVGRPYFVL QCDPEVLFLR
     RNIIDCVPLL EKAEKLIEFG SESPVFSKNR LLKLAQGLQQ FQDAKSNQVK FVQKMGQKEI
     MSFFETDFLC ATKWFTYLDE FQFLDKNQQL TLMQGIWHVW SRLHKLAVSA MGRRRGICDK
     NTVMVSHQNE FAVCDLNEIE VDMSWCTNFS NEQMRYFLDT SHDSYVYQVM DEMLGLKPND
     VELSYMMCQL CLQYAGQRFQ GEILEFCEKM LGFLADDLHS YYVKQLRMPN YAARLAKLMK
     INNRIKVDML KMRQRQEISR VFDIWTIDFS HPEFIQDANA C