NHR68_CAEEL
ID NHR68_CAEEL Reviewed; 385 AA.
AC Q9XXM8; Q86PK1;
DT 10-FEB-2021, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 174.
DE RecName: Full=Nuclear hormone receptor family member nhr-68 {ECO:0000312|WormBase:H12C20.3a};
GN Name=nhr-68 {ECO:0000312|WormBase:H12C20.3a};
GN ORFNames=H12C20.3 {ECO:0000312|WormBase:H12C20.3a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|EMBL:AAO39181.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15983867; DOI=10.1007/s00239-004-0175-8;
RA Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.;
RT "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4
RT in nematodes.";
RL J. Mol. Evol. 60:577-586(2005).
RN [2] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3] {ECO:0000305}
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=30625328; DOI=10.1016/j.celrep.2018.12.064;
RA Bulcha J.T., Giese G.E., Ali M.Z., Lee Y.U., Walker M.D., Holdorf A.D.,
RA Yilmaz L.S., Brewster R.C., Walhout A.J.M.;
RT "A Persistence Detector for Metabolic Network Rewiring in an Animal.";
RL Cell Rep. 26:460-468.e4(2019).
CC -!- FUNCTION: Probable transcription factor that acts in a feed-forward
CC loop with nhr-10 to activate genes, including itself, involved in the
CC vitamin B12-independent breakdown of the short-chain fatty acid
CC propionate (PubMed:30625328). This pathway is triggered in response to
CC a diet low in vitamin B12, when canonical vitamin B12-dependent
CC propionate breakdown cannot function; the resulting accumulation of
CC propionate is probably sensed by nhr-68 and/or nhr-10
CC (PubMed:30625328). {ECO:0000269|PubMed:30625328}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|RuleBase:RU004334}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown abolishes expression of
CC acdh-1 when diet is supplemented with 5 nM vitamin B12 and high levels
CC (40 mM) of propionate. {ECO:0000269|PubMed:30625328}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000255|RuleBase:RU004334}.
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DR EMBL; AY204177; AAO39181.1; -; mRNA.
DR EMBL; BX284605; CAA18351.1; -; Genomic_DNA.
DR PIR; T23065; T23065.
DR RefSeq; NP_001256334.1; NM_001269405.1.
DR AlphaFoldDB; Q9XXM8; -.
DR SMR; Q9XXM8; -.
DR STRING; 6239.H12C20.3a.1; -.
DR PaxDb; Q9XXM8; -.
DR EnsemblMetazoa; H12C20.3a.1; H12C20.3a.1; WBGene00003658.
DR UCSC; H12C20.3; c. elegans.
DR WormBase; H12C20.3a; CE18808; WBGene00003658; nhr-68.
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00970000196356; -.
DR HOGENOM; CLU_007368_3_3_1; -.
DR InParanoid; Q9XXM8; -.
DR OMA; CQFDQNC; -.
DR OrthoDB; 622732at2759; -.
DR PhylomeDB; Q9XXM8; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00003658; Expressed in larva and 3 other tissues.
DR ExpressionAtlas; Q9XXM8; baseline and differential.
DR GO; GO:0000785; C:chromatin; IMP:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IMP:UniProtKB.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0019543; P:propionate catabolic process; IMP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IMP:UniProtKB.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Metal-binding; Nucleus; Receptor;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..385
FT /note="Nuclear hormone receptor family member nhr-68"
FT /id="PRO_0000451998"
FT DOMAIN 145..384
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 4..79
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 7..27
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 43..62
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 81..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 373..384
FT /note="AF-2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT COMPBIAS 85..99
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 339
FT /note="Y -> F (in Ref. 1; AAO39181)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 385 AA; 44827 MW; 18D4C2A660825322 CRC64;
MENKEVCLVC QDFSSGYHYG IPSCNGCKTF FRRTVMKKQK FVCQFDQNCP VDKSIRCACR
FCRFEKCLKV GMDKTSLQAS RDPIGYTKRN KKTLRHPMNE LSGDESNSCT PDRQLSPLRS
FENSLNFLAV RERSANELRM SSYLPKRSLK QALCSKPLIN DPIFMSKHAT VSPRHTFEKL
RFITQDDYHY WHERDWFVLT EYAKTFKVFK NMPYHDKTEL VCHAAIVIPV LNQVYNSPDY
GLDTVVFPDG TYYDRTHEPT RPAGLNRKKY QVLDLVLKPF REMEINFNEF AAFKAITFLN
PDADISLESK HAINEERVLI TKQLYAYMVQ KDGLEKAIYR FGRLILMGTS MSKMACESKE
AVWIADFFEN IGFTSFAKEL IFGDH
