NHR69_CAEEL
ID NHR69_CAEEL Reviewed; 373 AA.
AC P91829;
DT 30-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 2.
DT 03-AUG-2022, entry version 169.
DE RecName: Full=Nuclear hormone receptor family member nhr-69;
GN Name=nhr-69; ORFNames=T23H4.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX PubMed=15983867; DOI=10.1007/s00239-004-0175-8;
RA Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.;
RT "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4
RT in nematodes.";
RL J. Mol. Evol. 60:577-586(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP FUNCTION, INTERACTION WITH DAF-8, SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=22359515; DOI=10.1371/journal.pgen.1002519;
RA Park D., Jones K.L., Lee H., Snutch T.P., Taubert S., Riddle D.L.;
RT "Repression of a potassium channel by nuclear hormone receptor and TGF-beta
RT signaling modulates insulin signaling in Caenorhabditis elegans.";
RL PLoS Genet. 8:e1002519-e1002519(2012).
CC -!- FUNCTION: Orphan nuclear receptor which, in cooperation with R-SMAD
CC daf-8, modulates the Insulin/IGF-1-like signaling (IIS) pathway,
CC perhaps by regulating expression of the potassium channel exp-2, which
CC in turn modulates the secretion of insulin-like peptide daf-28.
CC {ECO:0000269|PubMed:15983867, ECO:0000269|PubMed:22359515}.
CC -!- SUBUNIT: Interacts with R-SMAD daf-8. {ECO:0000269|PubMed:22359515}.
CC -!- INTERACTION:
CC P91829; P92004: tag-260; NbExp=3; IntAct=EBI-322112, EBI-316398;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407,
CC ECO:0000269|PubMed:22359515}.
CC -!- TISSUE SPECIFICITY: Expressed in the ASI neurons, hypodermis, and in
CC tail neurons. {ECO:0000269|PubMed:22359515}.
CC -!- DEVELOPMENTAL STAGE: Expressed in E8 intestinal precursor cells in
CC developing embryos, and in intestine throughout development into
CC adulthood. {ECO:0000269|PubMed:22359515}.
CC -!- DISRUPTION PHENOTYPE: On a temperature-sensitive daf-7 mutant
CC background, enhances entry of larvae into the developmentally arrested
CC state known as dauer, and also suppresses exit from dauer
CC (PubMed:22359515). Up-regulates expression of the potassium channel
CC exp-2 (PubMed:22359515). {ECO:0000269|PubMed:22359515}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY204178; AAO39182.1; -; mRNA.
DR EMBL; Z83240; CAB05815.2; -; Genomic_DNA.
DR PIR; T25211; T25211.
DR RefSeq; NP_492615.2; NM_060214.4.
DR AlphaFoldDB; P91829; -.
DR SMR; P91829; -.
DR BioGRID; 38263; 9.
DR DIP; DIP-24463N; -.
DR IntAct; P91829; 5.
DR MINT; P91829; -.
DR STRING; 6239.T23H4.2; -.
DR EPD; P91829; -.
DR PaxDb; P91829; -.
DR PeptideAtlas; P91829; -.
DR EnsemblMetazoa; T23H4.2.1; T23H4.2.1; WBGene00003659.
DR GeneID; 172840; -.
DR KEGG; cel:CELE_T23H4.2; -.
DR UCSC; T23H4.2.1; c. elegans.
DR CTD; 172840; -.
DR WormBase; T23H4.2; CE32501; WBGene00003659; nhr-69.
DR eggNOG; KOG4215; Eukaryota.
DR GeneTree; ENSGT00970000196158; -.
DR HOGENOM; CLU_007368_5_2_1; -.
DR InParanoid; P91829; -.
DR OMA; PVMILRD; -.
DR OrthoDB; 622732at2759; -.
DR PhylomeDB; P91829; -.
DR SignaLink; P91829; -.
DR PRO; PR:P91829; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00003659; Expressed in larva and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0046332; F:SMAD binding; IPI:WormBase.
DR GO; GO:1990239; F:steroid hormone binding; IDA:WormBase.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:WormBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..373
FT /note="Nuclear hormone receptor family member nhr-69"
FT /id="PRO_0000053795"
FT DOMAIN 93..344
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 3..78
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 6..26
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 42..66
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ SEQUENCE 373 AA; 41778 MW; 469B4471C8FB30F7 CRC64;
MVEEICHICN DKSTGKHYGA ISCDGCKGFF RRSIRKRYHY QCRFEQNCDV TKNKRNACRA
CRLQKCVKAG MKSNAIQNER DAIGKRKKTT GAEKEDLIDQ LVAAETLCQQ LRSSVIKNTS
SLAPYDCGKV KWNYEDARAA TLDDIGKSIH QQLVLFIEWA KSLPQFSFLA QADQAALLKG
GAASIIVLGV AYRSICLTVE NTICLANDTL LPKEHATQVG DINCVVGRII DEIVNPMRRL
NMDLIEYVAL KAILFFNPVV REINDQSPVE NARYAFLRSL QRRCTDKALE NMEDESMDCR
SGKLLLLLPS LQAIAQQLVE DVQLARLFGL VNVDSLMEEL ILNDMKPSDP QILQTSLASP
VNSSVKAEVE LEE
