NHR71_CAEEL
ID NHR71_CAEEL Reviewed; 579 AA.
AC Q9GTD4; G5EEW8; Q9GTD5; Q9TVX9;
DT 16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2004, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Nuclear hormone receptor family member nhr-71;
GN Name=nhr-71; ORFNames=K11E4.5;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15983867; DOI=10.1007/s00239-004-0175-8;
RA Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.;
RT "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4
RT in nematodes.";
RL J. Mol. Evol. 60:577-586(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Orphan nuclear receptor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=Q9GTD4-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q9GTD4-2; Sequence=VSP_053633;
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA94160.3; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAH60769.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF273824; AAG15173.1; -; mRNA.
DR EMBL; AF273825; AAG15174.1; -; mRNA.
DR EMBL; Z70211; CAA94160.3; ALT_INIT; Genomic_DNA.
DR EMBL; Z81550; CAA94160.3; JOINED; Genomic_DNA.
DR EMBL; Z70211; CAH60769.1; ALT_INIT; Genomic_DNA.
DR EMBL; Z81550; CAH60769.1; JOINED; Genomic_DNA.
DR PIR; B89694; B89694.
DR PIR; T22740; T22740.
DR RefSeq; NP_001024787.1; NM_001029616.4.
DR RefSeq; NP_001024788.1; NM_001029617.2.
DR AlphaFoldDB; Q9GTD4; -.
DR BioGRID; 46392; 3.
DR DIP; DIP-27345N; -.
DR IntAct; Q9GTD4; 3.
DR STRING; 6239.K11E4.5b; -.
DR EPD; Q9GTD4; -.
DR PaxDb; Q9GTD4; -.
DR PeptideAtlas; Q9GTD4; -.
DR EnsemblMetazoa; K11E4.5a.1; K11E4.5a.1; WBGene00003661.
DR EnsemblMetazoa; K11E4.5b.1; K11E4.5b.1; WBGene00003661.
DR GeneID; 181491; -.
DR KEGG; cel:CELE_K11E4.5; -.
DR UCSC; K11E4.5a; c. elegans. [Q9GTD4-1]
DR CTD; 181491; -.
DR WormBase; K11E4.5a; CE28244; WBGene00003661; nhr-71.
DR WormBase; K11E4.5b; CE37391; WBGene00003661; nhr-71.
DR eggNOG; KOG3575; Eukaryota.
DR InParanoid; Q9GTD4; -.
DR OrthoDB; 519616at2759; -.
DR PRO; PR:Q9GTD4; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00003661; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus; Receptor;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..579
FT /note="Nuclear hormone receptor family member nhr-71"
FT /id="PRO_0000053796"
FT DOMAIN 189..452
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 8..83
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 11..31
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 47..71
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 82..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 43
FT /note="A -> ALFQ (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_053633"
FT CONFLICT 330
FT /note="R -> E (in Ref. 1; AAG15173)"
FT /evidence="ECO:0000305"
FT CONFLICT 421
FT /note="L -> F (in Ref. 1; AAG15174)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 579 AA; 66691 MW; 76C01583A8AC39A8 CRC64;
MMKDEYNSQE CMVCSAPADG LHYGAISCRS CNAFFRRTVV EKAEYRCKHT NTCLIDPDGR
CACRSCRFTK CIEAGMKIGA VQPRRDPTGS QKERRKRAGG VGEMMSMNNS PLERNGNSFS
SDGPTSNSFI VDAIRTDYGF ATPRRISTDY SNSPDRYRKY VKIELDDEPI PSTSSAPEKQ
SCQSSPNDDE QQEFNHLVYA FGEHQRMMQL SFSTFEQFLD EHSNGPKLRR MDPLDVSKLS
AVELTGLLYW IEKQQPYGEL PVEDRSSLLK RYSVRKLSLD HFYSASKHPE YCARGEFVMN
NFTFVPADRT GFELPDDDPH QIQAKREHCR TFAPTFNRFW KNVIRPFVLM KVNDAEVVFL
HIMLLWSVTN NEHVTEDTRK VMKQRRDWAM NRLFDWYNEH GTSDPPLRFG QMILLLGEIE
LICDMHCQDF QVAKLFEFCD MSKFWYETLC YAPCNTNVLK FDPNLLENLK RFTAISVMEN
NGGLRPFVKT EIKQDPVLYS SPEVIAPESC YNDYQTVDIP VDCNPHTEPV SMDPNLANID
PAVLVFNAHM LPSVMAPLPD DADYHRPQLY HTQSEEVMT
