NHR76_CAEEL
ID NHR76_CAEEL Reviewed; 480 AA.
AC Q65CM0;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Nuclear hormone receptor family member nhr-76 {ECO:0000312|WormBase:C05G6.1};
GN Name=nhr-76 {ECO:0000312|WormBase:C05G6.1};
GN ORFNames=C05G6.1 {ECO:0000312|WormBase:C05G6.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=24120942; DOI=10.1016/j.cmet.2013.09.007;
RA Noble T., Stieglitz J., Srinivasan S.;
RT "An integrated serotonin and octopamine neuronal circuit directs the
RT release of an endocrine signal to control C. elegans body fat.";
RL Cell Metab. 18:672-684(2013).
CC -!- FUNCTION: Ligand-activated transcription factor (By similarity).
CC Involved in modulating serotonin-mediated induction of adipose
CC triglyceride lipase atgl-1, thereby regulating body fat
CC (PubMed:24120942). {ECO:0000250|UniProtKB:P24468,
CC ECO:0000269|PubMed:24120942}.
CC -!- INTERACTION:
CC Q65CM0; O45666: nhr-49; NbExp=4; IntAct=EBI-324921, EBI-318820;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- TISSUE SPECIFICITY: Expressed in the intestine.
CC {ECO:0000269|PubMed:24120942}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown abrogates the increase in
CC adipose triglyceride lipase atgl-1 expression seen in serotonin-treated
CC animals. {ECO:0000269|PubMed:24120942}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000255|RuleBase:RU004334}.
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DR EMBL; BX284604; CCD63287.1; -; Genomic_DNA.
DR RefSeq; NP_499961.2; NM_067560.4.
DR AlphaFoldDB; Q65CM0; -.
DR SMR; Q65CM0; -.
DR IntAct; Q65CM0; 6.
DR STRING; 6239.C05G6.1; -.
DR PaxDb; Q65CM0; -.
DR EnsemblMetazoa; C05G6.1.1; C05G6.1.1; WBGene00015497.
DR GeneID; 182276; -.
DR KEGG; cel:CELE_C05G6.1; -.
DR UCSC; C05G6.1; c. elegans.
DR CTD; 182276; -.
DR WormBase; C05G6.1; CE37476; WBGene00015497; nhr-76.
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00970000196300; -.
DR HOGENOM; CLU_538881_0_0_1; -.
DR InParanoid; Q65CM0; -.
DR OMA; EMGMNPS; -.
DR OrthoDB; 1671283at2759; -.
DR PhylomeDB; Q65CM0; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00015497; Expressed in adult organism and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:1904122; P:positive regulation of fatty acid beta-oxidation by octopamine signaling pathway; IMP:WormBase.
DR GO; GO:1904123; P:positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway; IMP:WormBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:WormBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..480
FT /note="Nuclear hormone receptor family member nhr-76"
FT /id="PRO_0000455110"
FT DOMAIN 233..480
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 75..155
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 78..99
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 115..138
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 24..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 470..480
FT /note="AF-2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
SQ SEQUENCE 480 AA; 53940 MW; 7B89D860A6951902 CRC64;
MEVLGKQKVL AMMKLNGAGQ LTGYPFETPS SSTTTPSVPP SFPHSSNPNA YMKPSPPSAI
SSPPSTSSCS SASEKKECAV CKNPNSSGYH FGCIACAACS AFFRRTVVLS RRYYCRRDPV
GNSLCPLDRR HRSNCRACRY VRCIDMGMNP SSVQNLRDSI KPRSPAEMIQ EAEEEDKKEK
LDDILFSAAT PGSWISSTST CNEPLPVAPK EIPGENYIET LAALYKNSVE RRRMFYCNGS
LREMLGGTGL KMRPTRFDER YYKEKMRFEL VLYVEMMNSM SVFRQMDLDT KETLVKGCAV
SLAMLEKYYI SVKYDGLRTQ KLIAPDGSYT DLSDHGAQFD DEFTQITESV MDKETCLKLL
YDPLRSCLNE LGSALEHSRM TDTEFCALFA ILLFNTAADN LSDASRNAVV MARNRVMKDW
FEFYAKQGID PHEAGLLVGN TLLLLTAVRN AMAVHRENFH VIRVFNVMEY DKLIDDLAFT
