NHR77_CAEEL
ID NHR77_CAEEL Reviewed; 362 AA.
AC O02316;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Nuclear hormone receptor family member nhr-77;
GN Name=nhr-77; ORFNames=T15D6.6;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Orphan nuclear receptor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
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DR EMBL; Z83125; CAB05622.2; -; Genomic_DNA.
DR PIR; T24931; T24931.
DR RefSeq; NP_493137.2; NM_060736.4.
DR AlphaFoldDB; O02316; -.
DR SMR; O02316; -.
DR STRING; 6239.T15D6.6; -.
DR PaxDb; O02316; -.
DR EnsemblMetazoa; T15D6.6.1; T15D6.6.1; WBGene00003667.
DR GeneID; 191726; -.
DR KEGG; cel:CELE_T15D6.6; -.
DR UCSC; T15D6.6; c. elegans.
DR CTD; 191726; -.
DR WormBase; T15D6.6; CE32209; WBGene00003667; nhr-77.
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00970000195849; -.
DR HOGENOM; CLU_066719_0_0_1; -.
DR InParanoid; O02316; -.
DR OrthoDB; 1214776at2759; -.
DR PhylomeDB; O02316; -.
DR PRO; PR:O02316; -.
DR Proteomes; UP000001940; Chromosome I.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..362
FT /note="Nuclear hormone receptor family member nhr-77"
FT /id="PRO_0000223581"
FT DOMAIN 145..362
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 8..82
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 11..32
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 48..69
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ SEQUENCE 362 AA; 42031 MW; 6BB91C2D75277215 CRC64;
MPIVELADPI CPVCEFPSNV ELHFGGLVCG ACAAFFRRTV SLNIRYLCEK NNQCKGMRKN
CRACRFDYCV KIAGMKRNLV KQRRNSTNTP MYILNRRKDS GNEEVVRGML KRMYLQFSSF
SGFVTTTQSK WAHHSRKSSM SPNKEAEKDV SKILKISHGS LLKYYIYQIT HDKRNNMNTL
NIKSVEEFLE ITSVQNKLAA ELCKTCPGVD LLDNEDILIL RKYFQFSNVW IESTWNYLRE
NNSVPIDDSE LDLKLLKFIN QVKSTLLVSF SQLKFNTIEF AAFKSICIWK LVYHETSRAM
KIIAQEHYES VMKALNDYYQ TYTSMDSMQI ATRIGEITLL IISVFQMYHD MAKLYIQLGL
PF
