ID   NHR7_CAEEL              Reviewed;         536 AA.
AC   Q20765;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 2.
DT   03-AUG-2022, entry version 164.
DE   RecName: Full=Nuclear hormone receptor family member nhr-7;
GN   Name=nhr-7; ORFNames=F54D1.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Bristol N2;
RX   PubMed=10022975;
RA   Sluder A.E., Mathews S.W., Hough D., Yin V.P., Maina C.V.;
RT   "The nuclear receptor superfamily has undergone extensive proliferation and
RT   diversification in nematodes.";
RL   Genome Res. 9:103-120(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Orphan nuclear receptor.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
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DR   EMBL; AF083225; AAD03683.1; -; mRNA.
DR   EMBL; Z77132; CAB00862.3; -; Genomic_DNA.
DR   PIR; T43349; T43349.
DR   RefSeq; NP_502117.2; NM_069716.5.
DR   AlphaFoldDB; Q20765; -.
DR   SMR; Q20765; -.
DR   STRING; 6239.F54D1.4; -.
DR   PaxDb; Q20765; -.
DR   EnsemblMetazoa; F54D1.4a.1; F54D1.4a.1; WBGene00003606.
DR   EnsemblMetazoa; F54D1.4a.2; F54D1.4a.2; WBGene00003606.
DR   GeneID; 178035; -.
DR   KEGG; cel:CELE_F54D1.4; -.
DR   UCSC; F54D1.4; c. elegans.
DR   CTD; 178035; -.
DR   WormBase; F54D1.4a; CE20866; WBGene00003606; nhr-7.
DR   eggNOG; KOG3575; Eukaryota.
DR   HOGENOM; CLU_038001_0_0_1; -.
DR   InParanoid; Q20765; -.
DR   OMA; FERNACR; -.
DR   OrthoDB; 740591at2759; -.
DR   PRO; PR:Q20765; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00003606; Expressed in larva and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0009755; P:hormone-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..536
FT                   /note="Nuclear hormone receptor family member nhr-7"
FT                   /id="PRO_0000053760"
FT   DOMAIN          155..378
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        6..82
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         9..29
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         46..70
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          427..465
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        436..465
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   536 AA;  60425 MW;  07B95116D41A4378 CRC64;
     MQSYTNRICA VCGDTPAKIH YGVLACFGCK GFFRRAVKDG RNKYVCRFEK NCEVTKFERN
     ACRYCRFRKC LLVGMNPDYV RPDREKSKKG KTVLSKKKSV SRSLSYRLAD PSDWTSFLSP
     SSRKQLSEIG KLAETCSTST NFDGIGNFSL KSLIADRSLA RKTGDSEAMD CSNSPRQLNE
     QFLGIERIVQ CVDYIDRFLV MLEEEHCRKF SVEDKSALIS DTMIHLLLFE STSRFVAKGA
     PGLEDLKLSL AQLPICTTHL TQKIADVFET YLRKPPSIIE YSVLKAYIVL SAESTVLSNS
     LNESLSLARE NLSELLFKVI KHSRNKTSIS AANSLSTILH FVYESRNLAS RIRQSQQPFF
     VRDSDPKIPF HKILTDIINP EVSDLLLTTA NCRKLSTQMG SSLSSVPPVP PPSDTVPLFH
     FSPPSLSPCQ ISAPPPPQQQ YTDYSQMPST SSYPANSSPF QSPYRPNSLS SFPKIPLEMT
     KSIEEFLRPN GMTTDEMNKP LEKNWADGFR LTPVFNKDIV SQFFPELSNI NQHHPF