NHR85_CAEEL
ID NHR85_CAEEL Reviewed; 514 AA.
AC Q9XUK7; Q6BER3;
DT 16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 2.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Nuclear hormone receptor family member nhr-85;
GN Name=nhr-85; ORFNames=W05B5.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
RX PubMed=15983867; DOI=10.1007/s00239-004-0175-8;
RA Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.;
RT "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4
RT in nematodes.";
RL J. Mol. Evol. 60:577-586(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Orphan nuclear receptor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=b;
CC IsoId=Q9XUK7-1; Sequence=Displayed;
CC Name=a;
CC IsoId=Q9XUK7-2; Sequence=VSP_007340;
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
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DR EMBL; AY204180; AAO39184.1; -; mRNA.
DR EMBL; AY204181; AAO39185.1; -; mRNA.
DR EMBL; Z82071; CAB04919.2; -; Genomic_DNA.
DR EMBL; AL110478; CAB04919.2; JOINED; Genomic_DNA.
DR EMBL; Z82071; CAH04734.1; -; Genomic_DNA.
DR PIR; T26189; T26189.
DR RefSeq; NP_001021667.1; NM_001026496.2. [Q9XUK7-1]
DR RefSeq; NP_001021668.1; NM_001026497.2. [Q9XUK7-2]
DR AlphaFoldDB; Q9XUK7; -.
DR SMR; Q9XUK7; -.
DR BioGRID; 56227; 6.
DR IntAct; Q9XUK7; 6.
DR STRING; 6239.W05B5.3a; -.
DR EPD; Q9XUK7; -.
DR PaxDb; Q9XUK7; -.
DR EnsemblMetazoa; W05B5.3a.1; W05B5.3a.1; WBGene00003675. [Q9XUK7-1]
DR EnsemblMetazoa; W05B5.3b.1; W05B5.3b.1; WBGene00003675. [Q9XUK7-2]
DR GeneID; 191732; -.
DR KEGG; cel:CELE_W05B5.3; -.
DR UCSC; W05B5.3b.2; c. elegans. [Q9XUK7-1]
DR CTD; 191732; -.
DR WormBase; W05B5.3a; CE26023; WBGene00003675; nhr-85. [Q9XUK7-1]
DR WormBase; W05B5.3b; CE20150; WBGene00003675; nhr-85. [Q9XUK7-2]
DR eggNOG; KOG4846; Eukaryota.
DR HOGENOM; CLU_585576_0_0_1; -.
DR InParanoid; Q9XUK7; -.
DR OMA; KCTGPIY; -.
DR OrthoDB; 972628at2759; -.
DR PhylomeDB; Q9XUK7; -.
DR PRO; PR:Q9XUK7; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00003675; Expressed in larva and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0009755; P:hormone-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus; Receptor;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..514
FT /note="Nuclear hormone receptor family member nhr-85"
FT /id="PRO_0000053797"
FT DOMAIN 216..514
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 110..186
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 113..133
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 150..174
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 28..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 465..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..502
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..178
FT /note="Missing (in isoform a)"
FT /evidence="ECO:0000303|PubMed:15983867"
FT /id="VSP_007340"
SQ SEQUENCE 514 AA; 56132 MW; D226A5A6FD7E96D9 CRC64;
MDLSTSGSLP CHLPLSLLTN LQTPPIDTSF SSPPATSSSS LLSPSPSSAF RPVVPKSLMN
PQPAMDTFYM SAIQSLVVST TNDDQYSEHG ALEGSKSLAK DENASTSAGT ILCQVCSDKA
SGFHYGVFAC EGCKGFFRRS IQQKITYRAC TRAEDCLILR NNRNRCQCCR LKKCLAVGMS
RDAVRFGRVP KREKARMFEE MQKTNVQSQR DQIAIQYENL TEVMHKINQA FGTLQATLEK
CTGPIYTDRC PITSNFIVIP LKAAIDFANS IPAFLSITQT QRVHLLQNSV FDVMLLASAS
ASTSQHFPPG GLTYDQSSAN PIIPQAIQSI SARIRQLPPQ TVPILTAIAV CQADLLPESQ
QPMLLAERLW CVLGKLGGIQ SLATAPSLLA DVRTLRQWHS DRLRQMSQIS QHFSQNLLIA
PVAAAAPVLL PPAFLSPPAS ATSTSSSSVK SEFIERHPSI ASLLERPRRI SSSGAQEPLN
LSLPHVRHQV KRDVDSDEQL EEMKVSPVPT TLSE
