ID   NHR86_CAEEL             Reviewed;         407 AA.
AC   Q965W2; Q9GTD1;
DT   30-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 2.
DT   03-AUG-2022, entry version 143.
DE   RecName: Full=Nuclear hormone receptor family member nhr-86;
GN   Name=nhr-86; ORFNames=Y40B10A.8;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15983867; DOI=10.1007/s00239-004-0175-8;
RA   Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.;
RT   "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4
RT   in nematodes.";
RL   J. Mol. Evol. 60:577-586(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Orphan nuclear receptor.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG15177.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AF273828; AAG15177.1; ALT_INIT; mRNA.
DR   EMBL; FO081304; CCD70636.1; -; Genomic_DNA.
DR   RefSeq; NP_503561.2; NM_071160.6.
DR   AlphaFoldDB; Q965W2; -.
DR   SMR; Q965W2; -.
DR   BioGRID; 43746; 2.
DR   IntAct; Q965W2; 1.
DR   STRING; 6239.Y40B10A.8.2; -.
DR   EPD; Q965W2; -.
DR   PaxDb; Q965W2; -.
DR   PRIDE; Q965W2; -.
DR   EnsemblMetazoa; Y40B10A.8a.1; Y40B10A.8a.1; WBGene00003676.
DR   GeneID; 178685; -.
DR   UCSC; Y40B10A.8; c. elegans.
DR   CTD; 178685; -.
DR   WormBase; Y40B10A.8a; CE31110; WBGene00003676; nhr-86.
DR   eggNOG; KOG3575; Eukaryota.
DR   GeneTree; ENSGT00940000168778; -.
DR   HOGENOM; CLU_007368_1_1_1; -.
DR   InParanoid; Q965W2; -.
DR   OMA; IHRKDGQ; -.
DR   OrthoDB; 978452at2759; -.
DR   PhylomeDB; Q965W2; -.
DR   PRO; PR:Q965W2; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00003676; Expressed in germ line (C elegans) and 4 other tissues.
DR   ExpressionAtlas; Q965W2; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IDA:WormBase.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..407
FT                   /note="Nuclear hormone receptor family member nhr-86"
FT                   /id="PRO_0000053798"
FT   DOMAIN          130..405
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        21..96
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         24..44
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         60..84
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ   SEQUENCE   407 AA;  46838 MW;  22DDB82F3072467E CRC64;
     MEPLDNTSLE ESQFRPEKKE KSTCSICRED GDGYHFGAEA CRACAAFFRR SVSLDKTYLC
     RGNNDCEITA NIRCMCRSCR FAKCLEVGMN PAGVQQRRDT IGKREIKPDS TDLMQLLGSV
     GDGYPPTTSA QSALVEDLHP SFNDRMPILM KMRVNYRKMD NARLVIHRKD GQSLFKEKTP
     KAVNYKEACA QSIREVSLVA DWVAWCFDDF VTLPMDQKKV LFRNFYTPFS VLEGAFLCHI
     NDTSNALILP SGDYIDTNNL KSFFNIPDEE QPMTDDEIEK FCRMFKPSFE LNRRGLVLPM
     MAEKIDVFEF FALCTFVFWD FGLDEQTDDC MMIGKSVKDR VMKELAFYLR CAKRLEEPSL
     RVASLLTLLP ALQRCVRRFQ EDIEITNVFN VYAPPKDFYD LVNGKFC