ID   NHR89_CAEEL             Reviewed;         310 AA.
AC   O02235; O17752;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 2.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Nuclear hormone receptor family member nhr-89;
GN   Name=nhr-89; ORFNames=E03H4.13;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Orphan nuclear receptor.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000305}.
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DR   EMBL; Z81492; CAB04035.1; -; Genomic_DNA.
DR   EMBL; Z83102; CAB04035.1; JOINED; Genomic_DNA.
DR   PIR; T20208; T20208.
DR   RefSeq; NP_493155.1; NM_060754.3.
DR   AlphaFoldDB; O02235; -.
DR   SMR; O02235; -.
DR   STRING; 6239.E03H4.13; -.
DR   PaxDb; O02235; -.
DR   PRIDE; O02235; -.
DR   EnsemblMetazoa; E03H4.13.1; E03H4.13.1; WBGene00003679.
DR   GeneID; 184026; -.
DR   KEGG; cel:CELE_E03H4.13; -.
DR   UCSC; E03H4.13; c. elegans.
DR   CTD; 184026; -.
DR   WormBase; E03H4.13; CE09139; WBGene00003679; nhr-89.
DR   eggNOG; KOG3575; Eukaryota.
DR   GeneTree; ENSGT00940000153391; -.
DR   HOGENOM; CLU_066719_0_0_1; -.
DR   InParanoid; O02235; -.
DR   OrthoDB; 1214776at2759; -.
DR   PhylomeDB; O02235; -.
DR   PRO; PR:O02235; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00105; zf-C4; 1.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..310
FT                   /note="Nuclear hormone receptor family member nhr-89"
FT                   /id="PRO_0000053799"
FT   DOMAIN          101..310
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        5..79
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         8..29
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         43..67
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ   SEQUENCE   310 AA;  35865 MW;  C64F6A488BB01D3C CRC64;
     MKIPEGPCRV CHSVKGTRRH FGITACMSCS SFFRRSLNCK FYCPANNSCT ILDDQKQFCR
     SCRYNKCVQS GMRRDCVRKQ SYRRQAGRKE AKSPAVSCSN KLSESYEELL NFYVKEANES
     IARKRQSPLK NAHQVKTSKE LLEISKSEDK TSLDAVLHCY GTYILDDEDI TTLIRYFKFM
     NTWIDSAFVY SKSTSNEELL DGNDICKFAY QIDTSIGLSL KNLNLNIFEY AALRAICIWN
     LKFYETSPKM KSLALEHYKG ITGALRQYYE NYMSDMDIAV RIGEITMQIT TISDLFHDLI
     TLHQKYQIPF