NHR8_CAEEL
ID NHR8_CAEEL Reviewed; 560 AA.
AC Q9XYB7; O44188; Q8MXI8;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=Nuclear hormone receptor family member nhr-8;
GN Name=nhr-8; ORFNames=F33D4.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
RC STRAIN=Bristol N2;
RX PubMed=10022975;
RA Sluder A.E., Mathews S.W., Hough D., Yin V.P., Maina C.V.;
RT "The nuclear receptor superfamily has undergone extensive proliferation and
RT diversification in nematodes.";
RL Genome Res. 9:103-120(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Orphan nuclear receptor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=Q9XYB7-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q9XYB7-2; Sequence=VSP_007343;
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
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DR EMBL; AF083226; AAD03684.1; -; mRNA.
DR EMBL; FO080445; CCD63761.1; -; Genomic_DNA.
DR EMBL; FO080445; CCD63762.1; -; Genomic_DNA.
DR PIR; T43350; T43350.
DR RefSeq; NP_001023169.1; NM_001027998.5. [Q9XYB7-2]
DR RefSeq; NP_741445.1; NM_171382.3. [Q9XYB7-1]
DR AlphaFoldDB; Q9XYB7; -.
DR SMR; Q9XYB7; -.
DR BioGRID; 42669; 29.
DR IntAct; Q9XYB7; 24.
DR STRING; 6239.F33D4.1a; -.
DR PaxDb; Q9XYB7; -.
DR EnsemblMetazoa; F33D4.1a.1; F33D4.1a.1; WBGene00003607. [Q9XYB7-1]
DR EnsemblMetazoa; F33D4.1b.1; F33D4.1b.1; WBGene00003607. [Q9XYB7-2]
DR GeneID; 177551; -.
DR KEGG; cel:CELE_F33D4.1; -.
DR UCSC; F33D4.1b; c. elegans. [Q9XYB7-1]
DR CTD; 177551; -.
DR WormBase; F33D4.1a; CE33927; WBGene00003607; nhr-8. [Q9XYB7-1]
DR WormBase; F33D4.1b; CE33928; WBGene00003607; nhr-8. [Q9XYB7-2]
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00940000153391; -.
DR InParanoid; Q9XYB7; -.
DR OMA; IMNSPFN; -.
DR OrthoDB; 297114at2759; -.
DR PhylomeDB; Q9XYB7; -.
DR Reactome; R-CEL-159418; Recycling of bile acids and salts.
DR Reactome; R-CEL-196791; Vitamin D (calciferol) metabolism.
DR Reactome; R-CEL-4090294; SUMOylation of intracellular receptors.
DR SignaLink; Q9XYB7; -.
DR PRO; PR:Q9XYB7; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00003607; Expressed in larva and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0004879; F:nuclear receptor activity; ISS:WormBase.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0042632; P:cholesterol homeostasis; IMP:WormBase.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus; Receptor;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..560
FT /note="Nuclear hormone receptor family member nhr-8"
FT /id="PRO_0000053761"
FT DOMAIN 336..560
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 23..98
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 26..46
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 62..86
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 188
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_007343"
SQ SEQUENCE 560 AA; 63317 MW; 60E74C437EC5C7A2 CRC64;
MPSSSPSMDE SRRSAVPPKE PAGRICTVCS DRANGYNFGV LTCESCKAFF RRNASKHKEI
KCPFSDSCQI TSASRKFCQA CRLNKCFAVG MNSEWLNDLK PKSSIVSGKF KRKKPDMKNN
LKVEVDDTEE DLENDDEEQI SVPKALLEKL INKANEKSKD RCTCKCQCGF YPITQRLTAY
EPKDTTAVNS PQDISFSHHL HHSDSFYSSS TSTLSPMSVI SCAPSSHDSS GYNTSQLVTQ
SPTNYTVSPA SIPSSITELS PQMPSQYPPM LSPFQFGVMA QMAAPANFLN FPPMPERTWT
PIQAVSTVPV TETLPPNLLE QIHSKIDKYI GVLNEDEITL LEELHVQNEP LNAPLIQWHN
PKSIDGVFRI IEEALRRIVN MACQLSLFRE LHVDDRKNLL KSGFGELLIV RGLMAYDKSD
NSWNHSFGVR GKMEVKVEVL KNPKLEEHYK AHMNLLSTFG EDVRNNEHLM LIFNAAVIFH
PHVSNLRDSK RVHSTQAKYF QMLLKLLTFE YGKSRADIAY SNLLNQVVEL HRVNRTLLRV
FYGLDIAQLD PLIRELCSFE
