NHR90_CAEEL
ID NHR90_CAEEL Reviewed; 393 AA.
AC O17025;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Nuclear hormone receptor family member nhr-90;
GN Name=nhr-90; ORFNames=ZK488.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Orphan nuclear receptor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
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DR EMBL; FO081423; CCD71522.1; -; Genomic_DNA.
DR PIR; T32237; T32237.
DR RefSeq; NP_503263.1; NM_070862.4.
DR AlphaFoldDB; O17025; -.
DR STRING; 6239.ZK488.2; -.
DR PaxDb; O17025; -.
DR EnsemblMetazoa; ZK488.2.1; ZK488.2.1; WBGene00003680.
DR GeneID; 178577; -.
DR KEGG; cel:CELE_ZK488.2; -.
DR UCSC; ZK488.2; c. elegans.
DR CTD; 178577; -.
DR WormBase; ZK488.2; CE28191; WBGene00003680; nhr-90.
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00970000196030; -.
DR HOGENOM; CLU_007368_7_1_1; -.
DR InParanoid; O17025; -.
DR OMA; CDRFQEV; -.
DR OrthoDB; 1686926at2759; -.
DR PhylomeDB; O17025; -.
DR PRO; PR:O17025; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00003680; Expressed in larva and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Receptor; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..393
FT /note="Nuclear hormone receptor family member nhr-90"
FT /id="PRO_0000223583"
FT DOMAIN 121..388
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 6..79
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 9..30
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 47..62
FT /note="NR C4-type; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
SQ SEQUENCE 393 AA; 45725 MW; 6D6DFA5C4A7F4BF9 CRC64;
MLVKSLQTCK ICGAENTRGN HFGVQCCRAC AVFFRRRAGT KYLRLKCLSV HCGEAARFCK
PCRLKRCYEA GMKIEYFQHN RDSIKSSSIA QIPRSFANIV GRPSLVIFCV PQDSYQKTFV
DLNSLVGKAS EIFTAGPESP YIGLTQLKKL ATFSNCSKEW AQTRFKTISH GEMSYFWEFY
FLRTAKWLTY FDEFQRIPDE IKIKLLLSFW HVFARLDKLI TTAKARKLKL CSQQTWAMSN
GLILDFDRTK VDFSDISNYP TEDLFYFLNS ITALDLQPQV LELMELEVSD MEFNFMLAQL
TFSYAGKRFQ GDILKICDRF QEVLSNDLHE YYVKEMRTPR YSGRLGKIMK INNAIQNDIW
KNRPRGELAA IFNVFKVEFS HPEMFIDTGF VRN
