NHR91_CAEEL
ID NHR91_CAEEL Reviewed; 474 AA.
AC Q9U2R6; Q6V7K9;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 2.
DT 03-AUG-2022, entry version 169.
DE RecName: Full=Nuclear hormone receptor family member nhr-91;
GN Name=nhr-91; ORFNames=Y15E3A.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
RC STRAIN=Bristol N2;
RX PubMed=14738886; DOI=10.1016/j.ydbio.2003.10.014;
RA Gissendanner C.R., Crossgrove K., Kraus K.A., Maina C.V., Sluder A.E.;
RT "Expression and function of conserved nuclear receptor genes in
RT Caenorhabditis elegans.";
RL Dev. Biol. 266:399-416(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Orphan nuclear receptor.
CC -!- INTERACTION:
CC Q9U2R6; A0A5E4M3Q4: syd-9; NbExp=4; IntAct=EBI-316939, EBI-329613;
CC Q9U2R6; P92004: tag-260; NbExp=3; IntAct=EBI-316939, EBI-316398;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=Q9U2R6-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q9U2R6-2; Sequence=VSP_020168;
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY349017; AAQ55497.1; -; mRNA.
DR EMBL; AY349018; AAQ55498.1; -; mRNA.
DR EMBL; AL132841; CAB60329.2; -; Genomic_DNA.
DR EMBL; AL132841; CAI46629.1; -; Genomic_DNA.
DR RefSeq; NP_001024953.1; NM_001029782.2. [Q9U2R6-1]
DR RefSeq; NP_001024954.1; NM_001029783.4.
DR AlphaFoldDB; Q9U2R6; -.
DR SMR; Q9U2R6; -.
DR BioGRID; 46518; 15.
DR DIP; DIP-27347N; -.
DR IntAct; Q9U2R6; 10.
DR MINT; Q9U2R6; -.
DR STRING; 6239.Y15E3A.1a.2; -.
DR EPD; Q9U2R6; -.
DR PaxDb; Q9U2R6; -.
DR EnsemblMetazoa; Y15E3A.1a.1; Y15E3A.1a.1; WBGene00003681. [Q9U2R6-1]
DR EnsemblMetazoa; Y15E3A.1a.2; Y15E3A.1a.2; WBGene00003681. [Q9U2R6-1]
DR EnsemblMetazoa; Y15E3A.1a.3; Y15E3A.1a.3; WBGene00003681. [Q9U2R6-1]
DR EnsemblMetazoa; Y15E3A.1b.1; Y15E3A.1b.1; WBGene00003681. [Q9U2R6-2]
DR EnsemblMetazoa; Y15E3A.1b.2; Y15E3A.1b.2; WBGene00003681. [Q9U2R6-2]
DR GeneID; 181621; -.
DR KEGG; cel:CELE_Y15E3A.1; -.
DR UCSC; Y15E3A.1b.3; c. elegans. [Q9U2R6-1]
DR CTD; 181621; -.
DR WormBase; Y15E3A.1a; CE27779; WBGene00003681; nhr-91. [Q9U2R6-1]
DR WormBase; Y15E3A.1b; CE38001; WBGene00003681; nhr-91. [Q9U2R6-2]
DR eggNOG; KOG3575; Eukaryota.
DR HOGENOM; CLU_001479_2_1_1; -.
DR InParanoid; Q9U2R6; -.
DR OMA; SPEAYVC; -.
DR OrthoDB; 717273at2759; -.
DR PhylomeDB; Q9U2R6; -.
DR SignaLink; Q9U2R6; -.
DR PRO; PR:Q9U2R6; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00003681; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus; Receptor;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..474
FT /note="Nuclear hormone receptor family member nhr-91"
FT /id="PRO_0000223584"
FT DOMAIN 215..474
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 97..172
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 100..120
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 136..155
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 50..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..164
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000303|PubMed:14738886"
FT /id="VSP_020168"
SQ SEQUENCE 474 AA; 53258 MW; 168B2A9A3D2AEF1E CRC64;
MDVADSTSET PPVFDHDNLA LAAQTNLLQF YLTHLASTLV PPMKLDMRDS MTPSFSQTES
PNSETDDSTS AANKVLFSIL GTPTTDSTSN AVSKSSSKLC SVCGDKSTGL HYGAATCEGC
KGFFKRSVQN KKVYHCSQDN CCEIDKQNRN RCQSCRFRKC ISKGMLTEAV REDRMPGGRN
GNSIYSNYKQ RRSIIRKTKD YVEEQERRPF QSLPSGKKLI KELVEMDCLD RLINLKGLRI
NPSANCDIAP ACKRLTRIGD EIVEQLVEWT KTLPFFDELP VEAHTHLLTQ RWAELVLLSA
GYYACSVFTP DSPDTTEMID ETDEISFTNP QVNLRLLQNR LSLVLGKEIP LEHVAKEAGP
LVTRFTTLLH SFSNLKVSPE AYVCIKAITL LHLSADSTLD RSIIDKVNTL QDHFVKTLQI
HLHQPGEDAQ TTSLAQILDW LPDLRNASSV LLHSKMFYVP FLLCKNPRRL VFDE
