NHR97_CAEEL
ID NHR97_CAEEL Reviewed; 439 AA.
AC Q9BJK5; Q2YS47; Q9XXL0;
DT 16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Nuclear hormone receptor family member nhr-97;
GN Name=nhr-97; ORFNames=H27C11.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
RX PubMed=15983867; DOI=10.1007/s00239-004-0175-8;
RA Robinson-Rechavi M., Maina C.V., Gissendanner C.R., Laudet V., Sluder A.;
RT "Explosive lineage-specific expansion of the orphan nuclear receptor HNF4
RT in nematodes.";
RL J. Mol. Evol. 60:577-586(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Orphan nuclear receptor.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=Q9BJK5-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q9BJK5-2; Sequence=VSP_020169;
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000305}.
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DR EMBL; AF332211; AAK17982.1; -; mRNA.
DR EMBL; AL022473; CAA18549.2; -; Genomic_DNA.
DR EMBL; Z82259; CAA18549.2; JOINED; Genomic_DNA.
DR EMBL; AL022473; CAJ43448.1; -; Genomic_DNA.
DR PIR; T23126; T23126.
DR RefSeq; NP_001040954.1; NM_001047489.3. [Q9BJK5-1]
DR RefSeq; NP_001040955.1; NM_001047490.2.
DR AlphaFoldDB; Q9BJK5; -.
DR SMR; Q9BJK5; -.
DR BioGRID; 42914; 1.
DR IntAct; Q9BJK5; 1.
DR STRING; 6239.H27C11.1a; -.
DR PaxDb; Q9BJK5; -.
DR EnsemblMetazoa; H27C11.1a.1; H27C11.1a.1; WBGene00003687. [Q9BJK5-1]
DR EnsemblMetazoa; H27C11.1a.2; H27C11.1a.2; WBGene00003687. [Q9BJK5-1]
DR EnsemblMetazoa; H27C11.1b.1; H27C11.1b.1; WBGene00003687. [Q9BJK5-2]
DR EnsemblMetazoa; H27C11.1b.2; H27C11.1b.2; WBGene00003687. [Q9BJK5-2]
DR GeneID; 177810; -.
DR KEGG; cel:CELE_H27C11.1; -.
DR UCSC; H27C11.1a; c. elegans. [Q9BJK5-1]
DR CTD; 177810; -.
DR WormBase; H27C11.1a; CE31027; WBGene00003687; nhr-97. [Q9BJK5-1]
DR WormBase; H27C11.1b; CE39262; WBGene00003687; nhr-97. [Q9BJK5-2]
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00940000153391; -.
DR HOGENOM; CLU_007368_3_3_1; -.
DR InParanoid; Q9BJK5; -.
DR OMA; VHHTNDK; -.
DR OrthoDB; 710326at2759; -.
DR PhylomeDB; Q9BJK5; -.
DR PRO; PR:Q9BJK5; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00003687; Expressed in larva and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 1.10.565.10; -; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF48508; SSF48508; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus; Receptor;
KW Reference proteome; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..439
FT /note="Nuclear hormone receptor family member nhr-97"
FT /id="PRO_0000053801"
FT DOMAIN 173..408
FT /note="NR LBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT DNA_BIND 32..108
FT /note="Nuclear receptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 35..56
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT ZN_FING 72..96
FT /note="NR C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 112..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..100
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_020169"
SQ SEQUENCE 439 AA; 49018 MW; 8891F0C6AAF55761 CRC64;
MSGDAQPSSN QRATEARPPP SPPLVNEKAA IGALCVVCGD RACSHLYYGV AACHGCKCFF
WRTVKSRLNY VCRYGGNCSI STAGRNACRY CRFHRCLFVG MKIEAVKMDR KLTKRKKEKT
DEDDTDDGGS HESFETTTDA KRAKFDNSLL ISSLQLIDKT SSAGNAKLST LHFVQPSLQN
LLDEPELLDG FRSEMSYRAT RQADEQLCYD SERRLVTWAI DWCRQTAEIA DVHHTNDKIS
LLRASCAPLV LLELGCQSSF GPSDTQIPFC NNSFLSAHCI PPSTSFLRWK TIQSLNKWAQ
RELKPLCLRA KEIVLLKALI ALNPDANGLS SDAESSIRML RERVHTALFQ LLMENSEPIT
AASRLAQILL LIPQLSLMGV DVIEQVKVRN TFNKRSAFGE GLLFWQLYGD IFDDANDDSY
LEHSASCSPT DSQYTTDSI
