NHSL2_MOUSE
ID NHSL2_MOUSE Reviewed; 1219 AA.
AC B1AXH1; E9Q0V6;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-APR-2019, sequence version 2.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=NHS-like protein 2 {ECO:0000305};
GN Name=Nhsl2 {ECO:0000312|MGI:MGI:3645090};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 936-1136.
RC STRAIN=C57BL/6J;
RX PubMed=14691545; DOI=10.1371/journal.pbio.0000074;
RA Sharov A.A., Piao Y., Matoba R., Dudekula D.B., Qian Y., VanBuren V.,
RA Falco G., Martin P.R., Stagg C.A., Bassey U.C., Wang Y., Carter M.G.,
RA Hamatani T., Aiba K., Akutsu H., Sharova L., Tanaka T.S., Kimber W.L.,
RA Yoshikawa T., Jaradat S.A., Pantano S., Nagaraja R., Boheler K.R., Taub D.,
RA Hodes R.J., Longo D.L., Schlessinger D., Keller J., Klotz E., Kelsoe G.,
RA Umezawa A., Vescovi A.L., Rossant J., Kunath T., Hogan B.L.M., Curci A.,
RA D'Urso M., Kelso J., Hide W., Ko M.S.H.;
RT "Transcriptome analysis of mouse stem cells and early embryos.";
RL PLoS Biol. 1:410-419(2003).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-499; SER-575; SER-690;
RP SER-1048 AND SER-1208, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Brain, Kidney, Lung, Pancreas, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the NHS family. {ECO:0000305}.
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DR EMBL; AL807784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL808026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CN666857; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS53156.1; -.
DR RefSeq; NP_001157082.1; NM_001163610.1.
DR AlphaFoldDB; B1AXH1; -.
DR BioGRID; 785739; 1.
DR IntAct; B1AXH1; 2.
DR MINT; B1AXH1; -.
DR STRING; 10090.ENSMUSP00000098893; -.
DR iPTMnet; B1AXH1; -.
DR PhosphoSitePlus; B1AXH1; -.
DR jPOST; B1AXH1; -.
DR MaxQB; B1AXH1; -.
DR PaxDb; B1AXH1; -.
DR PeptideAtlas; B1AXH1; -.
DR PRIDE; B1AXH1; -.
DR ProteomicsDB; 253063; -.
DR ProteomicsDB; 327084; -.
DR Antibodypedia; 35138; 14 antibodies from 6 providers.
DR Ensembl; ENSMUST00000101339; ENSMUSP00000098893; ENSMUSG00000079481.
DR GeneID; 100042480; -.
DR KEGG; mmu:100042480; -.
DR CTD; 340527; -.
DR MGI; MGI:3645090; Nhsl2.
DR VEuPathDB; HostDB:ENSMUSG00000079481; -.
DR eggNOG; ENOG502QQ7S; Eukaryota.
DR GeneTree; ENSGT00950000182963; -.
DR HOGENOM; CLU_009104_0_0_1; -.
DR InParanoid; B1AXH1; -.
DR OMA; EPEDPHQ; -.
DR OrthoDB; 82879at2759; -.
DR TreeFam; TF333323; -.
DR BioGRID-ORCS; 100042480; 4 hits in 72 CRISPR screens.
DR ChiTaRS; Nhsl2; mouse.
DR PRO; PR:B1AXH1; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; B1AXH1; protein.
DR Bgee; ENSMUSG00000079481; Expressed in internal carotid artery and 203 other tissues.
DR ExpressionAtlas; B1AXH1; baseline and differential.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR InterPro; IPR024845; NHS_fam.
DR Pfam; PF15273; NHS; 2.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..1219
FT /note="NHS-like protein 2"
FT /id="PRO_0000341356"
FT REGION 162..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 288..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 336..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 669..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 854..938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 979..1003
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1033..1087
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1121..1197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..543
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..568
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 669..691
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..733
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 857..872
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 873..894
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 900..915
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1128..1144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 499
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 575
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 690
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1048
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1208
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 1219 AA; 132353 MW; CA3C4C6BF415B6E1 CRC64;
MPFYRRTVVP QRLCPRNPPQ PLAELRDVSH LAALSLLRQL ADLCGHSLAL LEDLEGHLLA
LGRRTDSLYR RTVRLRRRLP CRLLGPEDDE ELLAAANSGR ENATATAHSR SSWRQPVNVF
LSSGRPPSVE ELLREAQLNL QSLLQEEYEE QYSEARLLGQ TFRSSDGAPE PTPSPRPQSA
KRLEFVLMPA KRQLSEDETT TQGVRAPEAC LSLSTANKQS AWNDPFPLPI LKERLWLQPC
STQSDLVPIN ISGQQFDRHA SFRHSLFNTE TAVNPKSTLR RRRTIIGFSN FSQRDQGHSS
SPTGSLARSA TSDIRPGHSA PQVVQGRVAV GQEARFPSLT SPGLRHSSSE PGDAHQARSA
SDHPGMESMA VVYSVPSSCN GPTESTFSTS WKGDAFTYMT PSASSQGNQV SENGKNPSSG
NSWVPLNTLP PLVPKEAATL FVTRDNPAGC TGLPSYSEHP TLRRQIPERP PKIGLLARGT
SRLETGPGGT NRFRERSLSV PTDSGVTSVD YDEEQKTSET RILPYASTSS EGSNSTDNIA
ALSTEQEARH RRQRSKSISL KKAKKKPSPP MRSVSLVKDE PALPPEGELV LPKDQRPRSL
CLSLEHQGHH PPHPDAQGHP AVPMLKDPGS TQFSHHWYLT DWKSGDTYQS LSSSSTATGT
TVIECTQVQG SSESLASPST SRATTPSQLS IEVEAREVAS PGRPTGLMSP SSGYSSQSET
PTPTVSMSLT LGHLPPPSAS VRVRPVVPER KSSLPPTSPM EKICKSRLSF DLPLTSSTTL
DLSGMSISIR SKTKVSRHHS DTNFGVKLAQ KTSPNQPIMP MVTQSDLRSV RLRSVSKSEP
EDDIESPDYI EEPGAEEVFT MPERKVKPPI AEKPPLARRP PSLVHRPPSL PGEYPLTSPT
MAMASRSSIP HMKQLPQDSY TVLRKPKSPS FPGESTASSS LVLSPLASSS GAFFSGTQQP
PQASVEDGGP KVRALPERIG LQSQEEAEKK MTKIPPPVPK KPSVLYLPLT SPVAQMDACM
AEPRLPFSPI ITLEEDGKCP STGDDQKSPG KGVTSPLHTD TEKEAISPGR SVEPSAEEKS
LISDKTAEWI AEEEDDVFVA SRTTEDLFTV IHRSKRKLLG WKETGEGFTG SKPSSHSPVK
NTADSPTGEA AAAPGPSSSA CLDAGRNDDF KALLQKKGSK ATPRTRPSAA ELLKTTNPLA
RRIIAQFSKD YEPTDNPST
