ID   NHSR_STRAS              Reviewed;         233 AA.
AC   P52392;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Putative nosiheptide resistance regulatory protein;
DE   AltName: Full=ORF699;
OS   Streptomyces actuosus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1885;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 25421 / DSM 40337 / JCM 4445 / NBRC 13009 / NRRL 2954 / VKM
RC   Ac-1274;
RX   PubMed=2401410; DOI=10.1016/0378-1119(90)90156-l;
RA   Li Y., Dosch D.C., Strohl W.R., Floss H.G.;
RT   "Nucleotide sequence and transcriptional analysis of the nosiheptide-
RT   resistance gene from Streptomyces actuosus.";
RL   Gene 91:9-17(1990).
CC   -!- FUNCTION: Seems to be involved in the regulation of nhs expression.
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DR   EMBL; U75434; AAB17874.1; -; Genomic_DNA.
DR   PIR; JQ0685; JQ0685.
DR   AlphaFoldDB; P52392; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   InterPro; IPR035214; DUF5324.
DR   Pfam; PF17258; DUF5324; 1.
PE   4: Predicted;
KW   Antibiotic resistance; DNA-binding; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..233
FT                   /note="Putative nosiheptide resistance regulatory protein"
FT                   /id="PRO_0000096809"
FT   DNA_BIND        93..112
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
FT   REGION          190..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        217..233
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   233 AA;  25037 MW;  4934E650A02F38B8 CRC64;
     MTRIDSVRAA TGSAKDSVLH AAEVVAPYAD TAKERAAHYA HEARVRLAPK VTLAAEQARV
     QYGAHLAPRL EQARTHVPPK VELAAQEAAL RTRKAARQAA DYSRPMIEQA VAAAGPVRDE
     AATRAAAALV ALRGQVTAED IQKLVRKHER RARTGRAVRM LAVLGLVAGG AFAAWKWWDK
     QANPDWLVEP PEATEVPESG RLTSVDGSAE AVLDPEVQAK EAAEEAAKRD DQA