NHX3_CAEEL
ID NHX3_CAEEL Reviewed; 670 AA.
AC O16452; Q71VC7; Q8T5S0;
DT 20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2003, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Probable Na(+)/H(+) antiporter nhx-3;
DE AltName: Full=Na(+)-H(+) exchanger protein 3;
GN Name=nhx-3; ORFNames=C54F6.13;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, SUBCELLULAR LOCATION, AND
RP TISSUE SPECIFICITY.
RX PubMed=12021279; DOI=10.1074/jbc.m203200200;
RA Nehrke K., Melvin J.E.;
RT "The NHX family of Na+-H+ exchangers in Caenorhabditis elegans.";
RL J. Biol. Chem. 277:29036-29044(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Plays a role in epithelial membrane transport processes.
CC {ECO:0000269|PubMed:12021279}.
CC -!- SUBCELLULAR LOCATION: Endomembrane system
CC {ECO:0000269|PubMed:12021279}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:12021279}. Note=Intracellular organelles.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=O16452-1; Sequence=Displayed;
CC Name=b;
CC IsoId=O16452-2; Sequence=VSP_015557;
CC -!- TISSUE SPECIFICITY: Expressed in hypodermal cells of the main body
CC syncytium, ut1 cells of the vulva and the spermathecal junction cell.
CC {ECO:0000269|PubMed:12021279}.
CC -!- PTM: Phosphorylated. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000305}.
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DR EMBL; AF497825; AAM18103.1; -; mRNA.
DR EMBL; FO080340; CCD62992.1; -; Genomic_DNA.
DR EMBL; FO080340; CCD62993.1; -; Genomic_DNA.
DR PIR; T31869; T31869.
DR RefSeq; NP_001023735.1; NM_001028564.2. [O16452-1]
DR RefSeq; NP_001023736.1; NM_001028565.1. [O16452-2]
DR AlphaFoldDB; O16452; -.
DR SMR; O16452; -.
DR STRING; 6239.C54F6.13a; -.
DR iPTMnet; O16452; -.
DR EPD; O16452; -.
DR PaxDb; O16452; -.
DR PeptideAtlas; O16452; -.
DR EnsemblMetazoa; C54F6.13a.1; C54F6.13a.1; WBGene00003731. [O16452-1]
DR EnsemblMetazoa; C54F6.13a.2; C54F6.13a.2; WBGene00003731. [O16452-1]
DR EnsemblMetazoa; C54F6.13b.1; C54F6.13b.1; WBGene00003731. [O16452-2]
DR GeneID; 183811; -.
DR KEGG; cel:CELE_C54F6.13; -.
DR UCSC; C54F6.13a; c. elegans. [O16452-1]
DR CTD; 183811; -.
DR WormBase; C54F6.13a; CE32044; WBGene00003731; nhx-3. [O16452-1]
DR WormBase; C54F6.13b; CE08985; WBGene00003731; nhx-3. [O16452-2]
DR eggNOG; KOG1966; Eukaryota.
DR InParanoid; O16452; -.
DR OMA; FLLICYA; -.
DR OrthoDB; 546232at2759; -.
DR PhylomeDB; O16452; -.
DR Reactome; R-CEL-2160916; Hyaluronan uptake and degradation.
DR Reactome; R-CEL-425986; Sodium/Proton exchangers.
DR PRO; PR:O16452; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00003731; Expressed in material anatomical entity and 3 other tissues.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015386; F:potassium:proton antiporter activity; IBA:GO_Central.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0051453; P:regulation of intracellular pH; IBA:GO_Central.
DR GO; GO:0098719; P:sodium ion import across plasma membrane; IBA:GO_Central.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR004709; NaH_exchanger.
DR PANTHER; PTHR10110; PTHR10110; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR PRINTS; PR01084; NAHEXCHNGR.
DR TIGRFAMs; TIGR00840; b_cpa1; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Antiport; Glycoprotein; Ion transport; Membrane;
KW Phosphoprotein; Reference proteome; Sodium; Sodium transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..670
FT /note="Probable Na(+)/H(+) antiporter nhx-3"
FT /id="PRO_0000052370"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..345
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 351..371
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 390..410
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 418..438
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 648..670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 310
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..29
FT /note="MLSKLFVFLLICYATADEVDKKEAKHGFQ -> MEVRDYGLAE (in
FT isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_015557"
SQ SEQUENCE 670 AA; 75546 MW; D976DE68DCD9E376 CRC64;
MLSKLFVFLL ICYATADEVD KKEAKHGFQL FHWNWDHIHK VYVITTWLLV ASLAKILFNL
MKPLSKWLPD SSLLIIVGLG LGYFLNQTTL SGVHLDSHAF FLYLLPPIIF DAGYFMPNRA
LFKNFDSVLV FSVLGTLWNT FAIGGSLLIM SKYQLFTMPF TTFEILVFSA LISAVDPVAV
IAIFEEIHVN EFLFINVFGE ALFNDGVTVV LYQMFKSFAL IGSENLSPWD YATGGLSFFV
VALGGAAIGI IFAIATSLAT KYTQGIKILA PVFIFLLPYM AYLTAEMVSL SSIIAIAVCG
MLMKQYIKGN ITEAATNSVK YFTKMLAQCS ETVIFMFLGL STLTSEHHVD FIFIGATLVF
CLIYRAIGII VQCFILNKFR AKKFEVVDQF ILSYGGLRGA IAYGLVVSIP ASIQAKPMFI
TTTICVIYFT VFLQGITIRP LVNCLNVKKK EHREATMVES VYNKYLDYMM SGVEDIAGQR
GHYSFIENFE RFNAKVIKPV LMRHEKRQSF DATSIIRAYE KITLEDAIKL TKVKSTLQNK
RLEKVKSEVR VAPEQTTVTP KDVQLARFMQ SGENIDQLYT LFSDLLDKKL NELKVQADKV
DKANDDDIQD DYMAEMGSHS NLGFMHHSAD QLDSDSVFQR RGRRLSTGDL KGHCGTSRKP
KHSMFELRHV
