NHX9_CAEEL
ID NHX9_CAEEL Reviewed; 667 AA.
AC P35449; Q95PV8; Q95PV9; Q95PW0;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 20-JUN-2002, sequence version 2.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Probable Na(+)/H(+) antiporter nhx-9;
DE AltName: Full=Na(+)-H(+) exchanger protein 9;
GN Name=nhx-9; ORFNames=ZK822.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
RX PubMed=12021279; DOI=10.1074/jbc.m203200200;
RA Nehrke K., Melvin J.E.;
RT "The NHX family of Na+-H+ exchangers in Caenorhabditis elegans.";
RL J. Biol. Chem. 277:29036-29044(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 58-667 (ISOFORMS A AND B).
RC STRAIN=Bristol N2;
RX PubMed=8382340; DOI=10.1007/bf00277125;
RA Marra M.A., Prasad S.S., Baillie D.L.;
RT "Molecular analysis of two genes between let-653 and let-56 in the unc-
RT 22(IV) region of Caenorhabditis elegans.";
RL Mol. Gen. Genet. 236:289-298(1993).
CC -!- FUNCTION: Serves some physiological function other than regulation of
CC cellular pH.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC Note=Excretory cell.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=b;
CC IsoId=P35449-1; Sequence=Displayed;
CC Name=a;
CC IsoId=P35449-2; Sequence=VSP_003395;
CC Name=c;
CC IsoId=P35449-3; Sequence=VSP_003396;
CC -!- TISSUE SPECIFICITY: In early stage larva, expressed in the twin
CC excretory cell processes. At later larval stages, expression is more
CC restricted, resulting in a 'beads on a chain' appearance.
CC -!- PTM: Phosphorylated. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000305}.
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DR EMBL; AF497834; AAM18112.1; -; mRNA.
DR EMBL; AF497835; AAM18113.1; -; mRNA.
DR EMBL; Z73898; CAC42388.1; -; Genomic_DNA.
DR EMBL; Z73898; CAC42389.1; -; Genomic_DNA.
DR EMBL; Z73898; CAC42390.3; -; Genomic_DNA.
DR EMBL; M23064; AAA27892.1; -; mRNA.
DR RefSeq; NP_001023627.1; NM_001028456.3. [P35449-2]
DR RefSeq; NP_001023628.1; NM_001028457.3. [P35449-1]
DR RefSeq; NP_001023629.2; NM_001028458.3.
DR AlphaFoldDB; P35449; -.
DR SMR; P35449; -.
DR STRING; 6239.ZK822.3b; -.
DR iPTMnet; P35449; -.
DR EPD; P35449; -.
DR PaxDb; P35449; -.
DR PeptideAtlas; P35449; -.
DR EnsemblMetazoa; ZK822.3a.1; ZK822.3a.1; WBGene00003736. [P35449-2]
DR EnsemblMetazoa; ZK822.3b.1; ZK822.3b.1; WBGene00003736. [P35449-1]
DR EnsemblMetazoa; ZK822.3c.1; ZK822.3c.1; WBGene00003736. [P35449-3]
DR GeneID; 178126; -.
DR KEGG; cel:CELE_ZK822.3; -.
DR UCSC; ZK822.3b; c. elegans. [P35449-1]
DR CTD; 178126; -.
DR WormBase; ZK822.3a; CE27559; WBGene00003736; nhx-9. [P35449-2]
DR WormBase; ZK822.3b; CE27560; WBGene00003736; nhx-9. [P35449-1]
DR WormBase; ZK822.3c; CE28196; WBGene00003736; nhx-9. [P35449-3]
DR eggNOG; KOG1966; Eukaryota.
DR InParanoid; P35449; -.
DR OMA; YWKDKFE; -.
DR OrthoDB; 546232at2759; -.
DR PhylomeDB; P35449; -.
DR Reactome; R-CEL-2160916; Hyaluronan uptake and degradation.
DR Reactome; R-CEL-425986; Sodium/Proton exchangers.
DR PRO; PR:P35449; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00003736; Expressed in larva and 4 other tissues.
DR GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015386; F:potassium:proton antiporter activity; IBA:GO_Central.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0051453; P:regulation of intracellular pH; IBA:GO_Central.
DR GO; GO:0098719; P:sodium ion import across plasma membrane; IBA:GO_Central.
DR GO; GO:0006814; P:sodium ion transport; NAS:UniProtKB.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR004709; NaH_exchanger.
DR PANTHER; PTHR10110; PTHR10110; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR PRINTS; PR01084; NAHEXCHNGR.
DR TIGRFAMs; TIGR00840; b_cpa1; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Antiport; Cell membrane; Glycoprotein; Ion transport;
KW Membrane; Phosphoprotein; Reference proteome; Sodium; Sodium transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..667
FT /note="Probable Na(+)/H(+) antiporter nhx-9"
FT /id="PRO_0000052371"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..345
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 351..371
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 390..410
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 418..438
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 637..667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 637..661
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 644
FT /note="Phosphothreonine"
FT /evidence="ECO:0000255"
FT CARBOHYD 310
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..60
FT /note="Missing (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_003396"
FT VAR_SEQ 1..29
FT /note="MSSRLFVFFLICYATADKIEKELISDGFQ -> MGHEYDIEE (in
FT isoform a)"
FT /evidence="ECO:0000303|PubMed:12021279,
FT ECO:0000303|PubMed:8382340"
FT /id="VSP_003395"
FT CONFLICT 111..112
FT /note="DA -> GSS (in Ref. 3; AAA27892)"
FT /evidence="ECO:0000305"
FT CONFLICT 214..217
FT /note="MFKS -> CSK (in Ref. 3; AAA27892)"
FT /evidence="ECO:0000305"
FT CONFLICT 415
FT /note="A -> R (in Ref. 3; AAA27892)"
FT /evidence="ECO:0000305"
FT CONFLICT 426
FT /note="V -> W (in Ref. 3; AAA27892)"
FT /evidence="ECO:0000305"
FT CONFLICT 625
FT /note="Missing (in Ref. 3; AAA27892)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 667 AA; 75281 MW; AB4245787973135B CRC64;
MSSRLFVFFL ICYATADKIE KELISDGFQL FTWKWDDVHH VYVITVWLLI ASLAKILFNL
MKPISKWCPD SSLLIIVGLA LGWILHQTSL SGATLDSHTF FLYLLPPIIF DAGYFMPNRA
LFENFDSVLV FSVFGTIWNT FAIGGSLLLM AQYDLFTMSF TTFEILVFSA LISAVDPVAV
IAVFEEIHVN EFLFINVFGE ALFNDGVTVV LYQMFKSFAL IGSENLSVLD YATGGLSFFV
VALGGAAVGI IFAIAASLTT KYTYDVRILA PVFIFVLPYM AYLTAEMVSL SSIIAIAICG
MLMKQYIKGN VTQAAANSVK YFTKMLAQSS ETVIFMFLGL STISSQHHFD LYFICATLFF
CLIYRAIGIV VQCYILNRFR AKKFEMVDQF IMSYGGLRGA IAYGLVVSIP ASITAKPMFI
TATIAVIYFT VFLQGITIRP LVNFLKIKKK EERDPTMVES VYNKYLDYMM SGVEDIAGQK
GHYTFIENFE RFNAKVIKPV LMRHQKRESF DASSIVRAYE KITLEDAIKL AKVKNNIQNK
RLERIKSKGR VAPILPDKIS NQKTMTPKDL QLKRFMESGE NIDSLYTLFS DLLDRKLHEM
NRPSVQITDV DGQDDIQDDY MAEVGSRSNL SAMFRSTEQL PSETPFHSGR RQSTGDLNAT
RRADFNV
