NIC1_SCHPO
ID NIC1_SCHPO Reviewed; 408 AA.
AC O74869; O74912;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2012, sequence version 3.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=High-affinity nickel transport protein nic1;
GN Name=nic1; ORFNames=SPCC1884.02, SPCC757.01;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP REVISION OF GENE MODEL.
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
RN [3]
RP FUNCTION.
RX PubMed=10748059; DOI=10.1074/jbc.m001978200;
RA Eitinger T., Degen O., Bohnke U., Muller M.;
RT "Nic1p, a relative of bacterial transition metal permeases in
RT Schizosaccharomyces pombe, provides nickel ion for urease biosynthesis.";
RL J. Biol. Chem. 275:18029-18033(2000).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: High-affinity nickel transporter responsible for nickel
CC uptake. Required for urease biosynthesis.
CC {ECO:0000269|PubMed:10748059}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:16823372}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the NiCoT transporter (TC 2.A.52) family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU329672; CAA21158.3; -; Genomic_DNA.
DR PIR; T41194; T41194.
DR RefSeq; NP_587676.3; NM_001022671.2.
DR AlphaFoldDB; O74869; -.
DR BioGRID; 275820; 7.
DR STRING; 4896.SPCC1884.02.1; -.
DR TCDB; 2.A.52.1.3; the ni(2+)-co(2+) transporter (nicot) family.
DR MaxQB; O74869; -.
DR PaxDb; O74869; -.
DR PRIDE; O74869; -.
DR EnsemblFungi; SPCC1884.02.1; SPCC1884.02.1:pep; SPCC1884.02.
DR GeneID; 2539250; -.
DR KEGG; spo:SPCC1884.02; -.
DR PomBase; SPCC1884.02; nic1.
DR VEuPathDB; FungiDB:SPCC1884.02; -.
DR eggNOG; ENOG502RIYK; Eukaryota.
DR HOGENOM; CLU_036094_0_1_1; -.
DR InParanoid; O74869; -.
DR OMA; NGWVLYK; -.
DR PRO; PR:O74869; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:PomBase.
DR GO; GO:0044750; F:high-affinity nickel cation transmembrane transporter activity; IMP:PomBase.
DR GO; GO:0098716; P:nickel cation import across plasma membrane; IMP:PomBase.
DR InterPro; IPR004688; Ni/Co_transpt.
DR InterPro; IPR011541; Ni/Co_transpt_high_affinity.
DR PANTHER; PTHR31611; PTHR31611; 1.
DR Pfam; PF03824; NicO; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Membrane; Nickel; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..408
FT /note="High-affinity nickel transport protein nic1"
FT /id="PRO_0000194003"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 333..353
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 408 AA; 45627 MW; 27246F79E3BA3819 CRC64;
MNSMSEYVKP RKNEFLRKFE NFYFEIPFLS KLPPKVSVPI FSLISVNIVV WIVAAIVISL
VNRSLFLSVL LSWTLGLRHA LDADHITAID NLTRRLLSTD KPMSTVGTWF SIGHSTVVLI
TCIVVAATSS KFADRWNNFQ TIGGIIGTSV SMGLLLLLAI GNTVLLVRLS YWLWMYRKSG
VTKDEGVTGF LARKMQRLFR LVDSPWKIYV LGFVFGLGFD TSTEVSLLGI ATLQALKGTS
IWAILLFPIV FLVGMCLVDT TDGALMYYAY SYSSGETNPY FSRLYYSIIL TFVSVIAAFT
IGIIQMLMLI ISVHPMESTF WNGLNRLSDN YEIVGGCICG AFVLAGLFGI SMHNYFKKKF
TPPVQVGNDR EDEVLEKNKE LENVSKNSIS VQISESEKVS YDTVDSKV
