NICN1_MOUSE
ID NICN1_MOUSE Reviewed; 213 AA.
AC Q9CQM0;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Nicolin-1;
DE AltName: Full=Tubulin polyglutamylase complex subunit 5;
DE Short=PGs5;
DE AltName: Full=p24;
GN Name=Nicn1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND TISSUE SPECIFICITY.
RC STRAIN=129S6/SvEvTac;
RX PubMed=12392556; DOI=10.1046/j.1432-1033.2002.03232.x;
RA Backofen B., Jacob R., Serth K., Gossler A., Naim H.Y., Leeb T.;
RT "Cloning and characterization of the mammalian-specific nicolin 1 gene
RT (NICN1) encoding a nuclear 24 kDa protein.";
RL Eur. J. Biochem. 269:5240-5245(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Hippocampus, and Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY AS PART OF THE TUBULIN POLYGLUTAMYLASE
RP COMPLEX.
RX PubMed=15890843; DOI=10.1126/science.1113010;
RA Janke C., Rogowski K., Wloga D., Regnard C., Kajava A.V., Strub J.-M.,
RA Temurak N., van Dijk J., Boucher D., van Dorsselaer A., Suryavanshi S.,
RA Gaertig J., Edde B.;
RT "Tubulin polyglutamylase enzymes are members of the TTL domain protein
RT family.";
RL Science 308:1758-1762(2005).
CC -!- SUBUNIT: Part of the neuronal tubulin polyglutamylase complex which
CC contains TPGS1, TPGS2, TTLL1, LRRC49 and NICN1.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: High expression level is found in brain, testis,
CC liver and kidney. Weak expression in spleen, leukocytes, small intestin
CC and colon. {ECO:0000269|PubMed:12392556}.
CC -!- DEVELOPMENTAL STAGE: Detected in all tissues of the developing embryos.
CC {ECO:0000269|PubMed:12392556}.
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DR EMBL; AJ299741; CAC82517.1; -; mRNA.
DR EMBL; AJ437692; CAD26916.1; -; Genomic_DNA.
DR EMBL; AK002789; BAB22360.1; -; mRNA.
DR EMBL; AK013602; BAB28922.1; -; mRNA.
DR EMBL; AK075732; BAC35916.1; -; mRNA.
DR EMBL; BC024050; AAH24050.1; -; mRNA.
DR CCDS; CCDS40767.1; -.
DR RefSeq; NP_079725.1; NM_025449.3.
DR AlphaFoldDB; Q9CQM0; -.
DR CORUM; Q9CQM0; -.
DR STRING; 10090.ENSMUSP00000035227; -.
DR iPTMnet; Q9CQM0; -.
DR PhosphoSitePlus; Q9CQM0; -.
DR MaxQB; Q9CQM0; -.
DR PaxDb; Q9CQM0; -.
DR PRIDE; Q9CQM0; -.
DR ProteomicsDB; 252963; -.
DR Antibodypedia; 30534; 73 antibodies from 16 providers.
DR DNASU; 66257; -.
DR Ensembl; ENSMUST00000035227; ENSMUSP00000035227; ENSMUSG00000032606.
DR GeneID; 66257; -.
DR KEGG; mmu:66257; -.
DR UCSC; uc009rpb.1; mouse.
DR CTD; 84276; -.
DR MGI; MGI:1913507; Nicn1.
DR VEuPathDB; HostDB:ENSMUSG00000032606; -.
DR eggNOG; ENOG502QQWA; Eukaryota.
DR GeneTree; ENSGT00390000001505; -.
DR HOGENOM; CLU_114995_0_0_1; -.
DR InParanoid; Q9CQM0; -.
DR OMA; TIHRTQM; -.
DR OrthoDB; 1638449at2759; -.
DR PhylomeDB; Q9CQM0; -.
DR TreeFam; TF329753; -.
DR BioGRID-ORCS; 66257; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Nicn1; mouse.
DR PRO; PR:Q9CQM0; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q9CQM0; protein.
DR Bgee; ENSMUSG00000032606; Expressed in ventromedial nucleus of hypothalamus and 261 other tissues.
DR Genevisible; Q9CQM0; MM.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR InterPro; IPR040235; Nicolin-1.
DR PANTHER; PTHR31239; PTHR31239; 1.
PE 1: Evidence at protein level;
KW Microtubule; Nucleus; Reference proteome.
FT CHAIN 1..213
FT /note="Nicolin-1"
FT /id="PRO_0000096815"
SQ SEQUENCE 213 AA; 24360 MW; 780F341FBA357173 CRC64;
MSRVLVPCHV KSTVALQVGD MRTSQGRPGV LVVDVTFPNI APFELQEIMF KNYYTAFLSI
RVRQQSSMHT AAKWVTCLRD YCLMPDPHSE EGAQDYVSLF KHQMLCDMNR VLELRLILRQ
PSPLWLSFTV EELQIYQQGP KSPSLAFPKW LSHPVSNEQP APRLEGLPDP SRVSSEVQQM
WALTEMIRAS HTSTRIGRFD VDGCYDLNLL SYT
