ID   NICP_PSEPK              Reviewed;         430 AA.
AC   Q88FY7;
DT   05-SEP-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Porin-like protein NicP;
DE   AltName: Full=Nicotinate degradation protein P;
DE   Flags: Precursor;
GN   Name=nicP; OrderedLocusNames=PP_3939;
OS   Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950
OS   / KT2440).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=160488;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440;
RX   PubMed=12534463; DOI=10.1046/j.1462-2920.2002.00366.x;
RA   Nelson K.E., Weinel C., Paulsen I.T., Dodson R.J., Hilbert H.,
RA   Martins dos Santos V.A.P., Fouts D.E., Gill S.R., Pop M., Holmes M.,
RA   Brinkac L.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Kolonay J.F.,
RA   Madupu R., Nelson W.C., White O., Peterson J.D., Khouri H.M., Hance I.,
RA   Chris Lee P., Holtzapple E.K., Scanlan D., Tran K., Moazzez A.,
RA   Utterback T.R., Rizzo M., Lee K., Kosack D., Moestl D., Wedler H.,
RA   Lauber J., Stjepandic D., Hoheisel J., Straetz M., Heim S., Kiewitz C.,
RA   Eisen J.A., Timmis K.N., Duesterhoeft A., Tuemmler B., Fraser C.M.;
RT   "Complete genome sequence and comparative analysis of the metabolically
RT   versatile Pseudomonas putida KT2440.";
RL   Environ. Microbiol. 4:799-808(2002).
RN   [2]
RP   FUNCTION.
RC   STRAIN=ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440;
RX   PubMed=18678916; DOI=10.1073/pnas.0802273105;
RA   Jimenez J.I., Canales A., Jimenez-Barbero J., Ginalski K., Rychlewski L.,
RA   Garcia J.L., Diaz E.;
RT   "Deciphering the genetic determinants for aerobic nicotinic acid
RT   degradation: the nic cluster from Pseudomonas putida KT2440.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:11329-11334(2008).
RN   [3]
RP   INDUCTION.
RC   STRAIN=ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440;
RX   PubMed=21450002; DOI=10.1111/j.1462-2920.2011.02471.x;
RA   Jimenez J.I., Juarez J.F., Garcia J.L., Diaz E.;
RT   "A finely tuned regulatory circuit of the nicotinic acid degradation
RT   pathway in Pseudomonas putida.";
RL   Environ. Microbiol. 13:1718-1732(2011).
CC   -!- FUNCTION: Probable transporter, possibly involved in the aerobic
CC       nicotinate degradation pathway. {ECO:0000305|PubMed:18678916}.
CC   -!- INDUCTION: Repressed by NicR in the absence of 6-hydroxynicotinate
CC       (6HNA) inducer. In presence of 6HNA, repression is alleviated.
CC       {ECO:0000269|PubMed:21450002}.
CC   -!- SIMILARITY: Belongs to the outer membrane porin (Opr) (TC 1.B.25)
CC       family. {ECO:0000305}.
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DR   EMBL; AE015451; AAN69533.1; -; Genomic_DNA.
DR   RefSeq; NP_746069.1; NC_002947.4.
DR   RefSeq; WP_010954761.1; NC_002947.4.
DR   AlphaFoldDB; Q88FY7; -.
DR   SMR; Q88FY7; -.
DR   STRING; 160488.PP_3939; -.
DR   TCDB; 1.B.25.1.37; the outer membrane porin (opr) family.
DR   EnsemblBacteria; AAN69533; AAN69533; PP_3939.
DR   KEGG; ppu:PP_3939; -.
DR   PATRIC; fig|160488.4.peg.4192; -.
DR   eggNOG; ENOG502Z9P4; Bacteria.
DR   HOGENOM; CLU_042378_2_1_6; -.
DR   OMA; QSRTQEW; -.
DR   PhylomeDB; Q88FY7; -.
DR   BioCyc; PPUT160488:G1G01-4204-MON; -.
DR   Proteomes; UP000000556; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.160.10; -; 1.
DR   InterPro; IPR005318; OM_porin_bac.
DR   InterPro; IPR023614; Porin_dom_sf.
DR   PANTHER; PTHR34596; PTHR34596; 1.
DR   Pfam; PF03573; OprD; 1.
PE   2: Evidence at transcript level;
KW   Aromatic hydrocarbons catabolism; Reference proteome; Signal; Transport.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..430
FT                   /note="Porin-like protein NicP"
FT                   /id="PRO_0000418476"
SQ   SEQUENCE   430 AA;  47048 MW;  E6E6791A42FC2912 CRC64;
     MQGFTAPRFS SSARLAGGCI AAALCAEATA EEAGFIEGAR ATLQARNYFF SRDYADIKGA
     STQSRTQEWA QGFILNASSG YTQGTLGVGV DVTGLLGFKL DSSPEHARSG LLPSLDSGKS
     ADEYSRLGAA IKFKVSQTEL KVGELMPNLP VLLFSDLRLL PPTYQGAMLE SREFAGLTLS
     AGQFRSTSLR DSSNSQKMYA LVNDPINPAR LARFTSDRFN YVGADYAFND NRTSVGVWQA
     QLEDIYQQRF YSFKHAEPLG SWTLGVNAGY FDAREDGSKV AGDYDNHALF SLFSAKTGGH
     TFYVGYQQIG GDDGFIQVGA NTNPMGNTLP TYEFSAPGER SWQVRHDYNF VALGLPGLTS
     TLRYVKGRDV ETGLGFEGRD RERDLDLAYV VQSGPLAGLG IRVRNVMARS NYRTDIDENR
     LILSYTIKVF