ID   NIF3L_BOVIN             Reviewed;         377 AA.
AC   Q05B89;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=NIF3-like protein 1 {ECO:0000305};
GN   Name=NIF3L1 {ECO:0000250|UniProtKB:Q9GZT8};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May function as a transcriptional corepressor through its
CC       interaction with COPS2, negatively regulating the expression of genes
CC       involved in neuronal differentiation. {ECO:0000250|UniProtKB:Q9EQ80}.
CC   -!- SUBUNIT: Homodimer. Interacts with COPS2. Interacts with THOC7.
CC       {ECO:0000250|UniProtKB:Q9GZT8}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9EQ80}. Nucleus
CC       {ECO:0000250|UniProtKB:Q9EQ80}. Note=Interaction with COPS2 may
CC       regulate localization to the nucleus. {ECO:0000250|UniProtKB:Q9EQ80}.
CC   -!- SIMILARITY: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
CC       {ECO:0000305}.
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DR   EMBL; BC122596; AAI22597.1; -; mRNA.
DR   RefSeq; NP_001073718.1; NM_001080249.2.
DR   RefSeq; XP_005202674.1; XM_005202617.3.
DR   AlphaFoldDB; Q05B89; -.
DR   SMR; Q05B89; -.
DR   STRING; 9913.ENSBTAP00000024331; -.
DR   PaxDb; Q05B89; -.
DR   PRIDE; Q05B89; -.
DR   Ensembl; ENSBTAT00000024331; ENSBTAP00000024331; ENSBTAG00000018282.
DR   GeneID; 509473; -.
DR   KEGG; bta:509473; -.
DR   CTD; 60491; -.
DR   VEuPathDB; HostDB:ENSBTAG00000018282; -.
DR   VGNC; VGNC:32075; NIF3L1.
DR   eggNOG; KOG4131; Eukaryota.
DR   GeneTree; ENSGT00390000003590; -.
DR   HOGENOM; CLU_037423_0_0_1; -.
DR   InParanoid; Q05B89; -.
DR   OMA; EVAYDIY; -.
DR   OrthoDB; 1293706at2759; -.
DR   TreeFam; TF324125; -.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000018282; Expressed in oocyte and 104 other tissues.
DR   ExpressionAtlas; Q05B89; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:1903507; P:negative regulation of nucleic acid-templated transcription; ISS:UniProtKB.
DR   GO; GO:0030182; P:neuron differentiation; ISS:UniProtKB.
DR   InterPro; IPR002678; DUF34/NIF3.
DR   InterPro; IPR017222; DUF34/NIF3_animal.
DR   InterPro; IPR036069; DUF34/NIF3_sf.
DR   PANTHER; PTHR13799; PTHR13799; 1.
DR   Pfam; PF01784; NIF3; 1.
DR   PIRSF; PIRSF037490; UCP037490_NIF3_euk; 1.
DR   SUPFAM; SSF102705; SSF102705; 1.
DR   TIGRFAMs; TIGR00486; YbgI_SA1388; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..377
FT                   /note="NIF3-like protein 1"
FT                   /id="PRO_0000330908"
FT   REGION          244..377
FT                   /note="Mediates interaction with COPS2"
FT                   /evidence="ECO:0000250|UniProtKB:Q9EQ80"
FT   MOD_RES         109
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9GZT8"
FT   MOD_RES         255
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9EQ80"
FT   MOD_RES         259
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9EQ80"
SQ   SEQUENCE   377 AA;  41906 MW;  33205D86C93D92CD CRC64;
     MLSSRVRLVA TTARLVHSLI YSSSRSFMDL KALLSSLNDF ASLSFAESWD NVGLLVEPSP
     PHTVNTLFLT NDLTEEVMEE ALQKKADLIL SYHPPIFRPM KRITWKTWKE RLVIRALENR
     VGIYSPHTAY DAAPQGVNNW LAKGLGVCTS RPIHPSKAPD YPTEGTHRVE FSVTHTQDPD
     KVISALKEIA GVSVTSFSAR TDDEEQTRLS LNCTQQALMQ VVAFLSQNRQ FYQKTEILSL
     EKPLLLYTGM GRLCTLDESV SLETMIERIK SHLKLSHVRL ALGIGKTLES PVKVVALCAG
     SGSSVLQGTD ADLYLTGEMS HHDVLDAASQ GISVILCEHS NTERGFLSDL RDMLDAHLEN
     KINIILSETD RDPLHVI