ID   NIF3L_RAT               Reviewed;         376 AA.
AC   Q4V7D6;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=NIF3-like protein 1 {ECO:0000305|PubMed:12522100};
GN   Name=Nif3l1 {ECO:0000312|RGD:1310329};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   INTERACTION WITH COPS2.
RX   PubMed=12522100; DOI=10.1074/jbc.m209856200;
RA   Akiyama H., Fujisawa N., Tashiro Y., Takanabe N., Sugiyama A., Tashiro F.;
RT   "The role of transcriptional corepressor Nif3l1 in early stage of neural
RT   differentiation via cooperation with Trip15/CSN2.";
RL   J. Biol. Chem. 278:10752-10762(2003).
CC   -!- FUNCTION: May function as a transcriptional corepressor through its
CC       interaction with COPS2, negatively regulating the expression of genes
CC       involved in neuronal differentiation. {ECO:0000250|UniProtKB:Q9EQ80}.
CC   -!- SUBUNIT: Homodimer (By similarity). Interacts with COPS2
CC       (PubMed:12522100). Interacts with THOC7 (By similarity).
CC       {ECO:0000250|UniProtKB:Q9GZT8, ECO:0000269|PubMed:12522100}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9EQ80}. Nucleus
CC       {ECO:0000250|UniProtKB:Q9EQ80}. Note=Interaction with COPS2 may
CC       regulate localization to the nucleus. {ECO:0000250|UniProtKB:Q9EQ80}.
CC   -!- SIMILARITY: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
CC       {ECO:0000305}.
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DR   EMBL; BC097992; AAH97992.1; -; mRNA.
DR   RefSeq; XP_006245023.1; XM_006244961.3.
DR   RefSeq; XP_006245024.1; XM_006244962.3.
DR   AlphaFoldDB; Q4V7D6; -.
DR   SMR; Q4V7D6; -.
DR   STRING; 10116.ENSRNOP00000018014; -.
DR   iPTMnet; Q4V7D6; -.
DR   PhosphoSitePlus; Q4V7D6; -.
DR   jPOST; Q4V7D6; -.
DR   PaxDb; Q4V7D6; -.
DR   GeneID; 301431; -.
DR   UCSC; RGD:1310329; rat.
DR   CTD; 60491; -.
DR   RGD; 1310329; Nif3l1.
DR   VEuPathDB; HostDB:ENSRNOG00000013446; -.
DR   eggNOG; KOG4131; Eukaryota.
DR   HOGENOM; CLU_037423_0_0_1; -.
DR   InParanoid; Q4V7D6; -.
DR   OMA; EVAYDIY; -.
DR   OrthoDB; 1293706at2759; -.
DR   PhylomeDB; Q4V7D6; -.
DR   TreeFam; TF324125; -.
DR   PRO; PR:Q4V7D6; -.
DR   Proteomes; UP000002494; Chromosome 9.
DR   Bgee; ENSRNOG00000013446; Expressed in pancreas and 19 other tissues.
DR   ExpressionAtlas; Q4V7D6; baseline and differential.
DR   Genevisible; Q4V7D6; RN.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; ISO:RGD.
DR   GO; GO:1903507; P:negative regulation of nucleic acid-templated transcription; ISS:UniProtKB.
DR   GO; GO:0030182; P:neuron differentiation; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:RGD.
DR   InterPro; IPR002678; DUF34/NIF3.
DR   InterPro; IPR017222; DUF34/NIF3_animal.
DR   InterPro; IPR036069; DUF34/NIF3_sf.
DR   PANTHER; PTHR13799; PTHR13799; 1.
DR   Pfam; PF01784; NIF3; 1.
DR   PIRSF; PIRSF037490; UCP037490_NIF3_euk; 1.
DR   SUPFAM; SSF102705; SSF102705; 1.
DR   TIGRFAMs; TIGR00486; YbgI_SA1388; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..376
FT                   /note="NIF3-like protein 1"
FT                   /id="PRO_0000330909"
FT   REGION          243..376
FT                   /note="Mediates interaction with COPS2"
FT                   /evidence="ECO:0000250|UniProtKB:Q9EQ80"
FT   MOD_RES         108
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9GZT8"
FT   MOD_RES         254
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9EQ80"
FT   MOD_RES         258
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9EQ80"
SQ   SEQUENCE   376 AA;  41519 MW;  026B28FA7CC412B3 CRC64;
     MLSSAHVVPT SVRRAPSWIC SSSRSFMDLK ALLSSLNDFA SLSFAESWDN VGLLVEPSPP
     HTVNTLFLTN DLTEEVMEEA LQKKADLILS YHPPIFRPMK HITWKTWKER LVIRALENRV
     AIYSPHTAYD AAPQGVNSWL AKGLGTCTTR PIHPSKAPNY PTEGTHRLEF SANHSQDLDK
     VMSAVKGVGG VSVTSFPARC DGEEQTRVSL NCTQKALMQV LAFLSQDRQL YQKTEILSLE
     KPLLLHTGMG RLCTLDESVS LATMIERIKR HLKLPHLRLA LGVGRTLESP VKVVALCAGS
     GGSVLQGVEA DLYLTGEMSH HDVLDAASKG INVILCEHSN TERGFLSDLQ EMLGVHLENK
     INIILSETDR DPLRVV