ID   NIFE_METTH              Reviewed;         478 AA.
AC   O27607;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Nitrogenase iron-molybdenum cofactor biosynthesis protein NifE;
GN   Name=nifE; OrderedLocusNames=MTH_1565;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- FUNCTION: This protein may play a role in the biosynthesis of the
CC       prosthetic group of nitrogenase (FeMo cofactor).
CC   -!- PATHWAY: Cofactor biosynthesis; Fe-Mo cofactor biosynthesis.
CC   -!- SIMILARITY: Belongs to the NifD/NifK/NifE/NifN family. {ECO:0000305}.
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DR   EMBL; AE000666; AAB86039.1; -; Genomic_DNA.
DR   PIR; H69075; H69075.
DR   RefSeq; WP_010877174.1; NC_000916.1.
DR   AlphaFoldDB; O27607; -.
DR   SMR; O27607; -.
DR   STRING; 187420.MTH_1565; -.
DR   EnsemblBacteria; AAB86039; AAB86039; MTH_1565.
DR   GeneID; 1471834; -.
DR   KEGG; mth:MTH_1565; -.
DR   PATRIC; fig|187420.15.peg.1528; -.
DR   HOGENOM; CLU_025876_1_1_2; -.
DR   OMA; SWDNRGT; -.
DR   UniPathway; UPA00782; -.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0016163; F:nitrogenase activity; IEA:InterPro.
DR   GO; GO:0009399; P:nitrogen fixation; IEA:UniProtKB-KW.
DR   GO; GO:0065003; P:protein-containing complex assembly; IEA:InterPro.
DR   InterPro; IPR000510; Nase/OxRdtase_comp1.
DR   InterPro; IPR000318; Nase_comp1_CS.
DR   InterPro; IPR005973; NifE.
DR   Pfam; PF00148; Oxidored_nitro; 1.
DR   TIGRFAMs; TIGR01283; nifE; 1.
DR   PROSITE; PS00699; NITROGENASE_1_1; 1.
DR   PROSITE; PS00090; NITROGENASE_1_2; 1.
PE   3: Inferred from homology;
KW   Nitrogen fixation; Reference proteome.
FT   CHAIN           1..478
FT                   /note="Nitrogenase iron-molybdenum cofactor biosynthesis
FT                   protein NifE"
FT                   /id="PRO_0000153118"
SQ   SEQUENCE   478 AA;  52909 MW;  AE0285E766E46BFE CRC64;
     MNHSTGNSSN NKEFPGSNLE FQVGHVDRVI DTIPSRRGHF KRSGGGGPCC NKASVPGMVT
     QRSCVYGGAR VVLMPITDAA HIVHGPVGCA ACTWDIRGSR SSKSDLYKTG FSTNLEEKDV
     VFGGEDRLLK CILEVDEIYS PSAIFVYSTC VSGVIGDDIT AVCRNAEYKT GKWVIPVQSE
     GFRSFNKSLG HQLACDVLLD HVIGRGDAEV GERSVNLVGE FNVAGDLWEI KRLLEKMGVK
     VVASITGDST VAEISAAHKA QLNLVQCSKS SGYIAEEMEK RHGTPHINVN FFGMRETMDS
     LISISEFFGL ELAEKWVLGM VEETKRKVAR YRNTLEGKKV AIYVGGNKAW SLIRAFEDLG
     MEVIMSGTQN GLPNDYLRIM EKSGRELILF DDANPVELSR LLNKYRPDLF VSGAKEKYLS
     YKLGIPFCEF NHDRIKPFSC FRGFLNFAEE VDKAVNSRVW KLAAPRTFLN CGVEYGYE