NIG2A_ODOHO
ID NIG2A_ODOHO Reviewed; 21 AA.
AC P0C8U0;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 16.
DE RecName: Full=Nigrocin-2HSa;
OS Odorrana hosii (Hose's rock frog) (Rana hosii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Odorrana.
OX NCBI_TaxID=310666;
RN [1]
RP PROTEIN SEQUENCE, FUNCTION, AND MASS SPECTROMETRY.
RC TISSUE=Skin secretion;
RX PubMed=18621071; DOI=10.1016/j.toxicon.2008.06.017;
RA Conlon J.M., Kolodziejek J., Nowotny N., Leprince J., Vaudry H., Coquet L.,
RA Jouenne T., King J.D.;
RT "Characterization of antimicrobial peptides from the skin secretions of the
RT Malaysian frogs, Odorrana hosii and Hylarana picturata (Anura:Ranidae).";
RL Toxicon 52:465-473(2008).
CC -!- FUNCTION: Has antibacterial activity against the Gram-positive
CC bacterium S.aureus ATCC 25923 (MIC=56 uM) and the Gram-negative
CC bacterium E.coli ATCC 25726 (MIC=28 uM). {ECO:0000269|PubMed:18621071}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC -!- MASS SPECTROMETRY: Mass=1962.0; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:18621071};
CC -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC Brevinin subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; P0C8U0; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IEA:UniProt.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:UniProt.
DR InterPro; IPR032749; Nigrocin.
DR Pfam; PF16047; Antimicrobial22; 1.
PE 1: Evidence at protein level;
KW Amphibian defense peptide; Antibiotic; Antimicrobial;
KW Direct protein sequencing; Disulfide bond; Secreted.
FT PEPTIDE 1..21
FT /note="Nigrocin-2HSa"
FT /id="PRO_0000366048"
FT DISULFID 15..21
SQ SEQUENCE 21 AA; 1965 MW; FA54E4D025E3433D CRC64;
GLLGSLFGAG KKVACALSGL C