NIG2B_ODOGR
ID NIG2B_ODOGR Reviewed; 21 AA.
AC C0HL73;
DT 28-FEB-2018, integrated into UniProtKB/Swiss-Prot.
DT 28-FEB-2018, sequence version 1.
DT 25-MAY-2022, entry version 7.
DE RecName: Full=Nigrocin-2GRb {ECO:0000303|PubMed:16621155};
OS Odorrana grahami (Yunnanfu frog) (Rana grahami).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Odorrana.
OX NCBI_TaxID=167935 {ECO:0000303|PubMed:16621155};
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, FUNCTION, AND MASS SPECTROMETRY.
RC TISSUE=Skin {ECO:0000303|PubMed:16621155};
RX PubMed=16621155; DOI=10.1016/j.peptides.2006.03.002;
RA Conlon J.M., Al-Ghaferi N., Abraham B., Jiansheng H., Cosette P.,
RA Leprince J., Jouenne T., Vaudry H.;
RT "Antimicrobial peptides from diverse families isolated from the skin of the
RT Asian frog, Rana grahami.";
RL Peptides 27:2111-2117(2006).
CC -!- FUNCTION: Antimicrobial peptide active against the Gram-positive
CC bacterium S.aureus (MIC=12.5 uM) and against the Gram-negative bacteria
CC E.coli (MIC=3 uM). Has antifungal activity against C.albicans (MIC=50
CC uM). Has some hemolytic activity against human erythrocytes (LC(50)=40
CC uM). {ECO:0000269|PubMed:16621155}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P85071}.
CC -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC {ECO:0000305|PubMed:16621155}.
CC -!- MASS SPECTROMETRY: Mass=2077.0; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:16621155};
CC -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC Brevinin subfamily. {ECO:0000305}.
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DR AlphaFoldDB; C0HL73; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0051715; P:cytolysis in another organism; IDA:UniProtKB.
DR GO; GO:0050832; P:defense response to fungus; IDA:UniProtKB.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
DR GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IDA:UniProtKB.
DR InterPro; IPR032749; Nigrocin.
DR Pfam; PF16047; Antimicrobial22; 1.
PE 1: Evidence at protein level;
KW Antibiotic; Antimicrobial; Cytolysis; Direct protein sequencing; Fungicide;
KW Hemolysis; Secreted.
FT PEPTIDE 1..21
FT /note="Nigrocin-2GRb"
FT /evidence="ECO:0000269|PubMed:16621155"
FT /id="PRO_0000443436"
SQ SEQUENCE 21 AA; 2081 MW; 0689D9BD576DEB91 CRC64;
GLFGKILGVG KKVLCGLSGM C