NIJB_DROME
ID NIJB_DROME Reviewed; 181 AA.
AC Q9VVT9; Q4V5W5;
DT 02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Ninjurin-B {ECO:0000303|PubMed:16815999};
DE Short=dNINJ-B {ECO:0000303|PubMed:33472215};
GN Name=NijB {ECO:0000303|PubMed:16815999, ECO:0000312|FlyBase:FBgn0036822};
GN ORFNames=CG11637 {ECO:0000312|FlyBase:FBgn0036822};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:AAY54957.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-181.
RA Stapleton M., Carlson J., Chavez C., Frise E., George R., Pacleb J.,
RA Park S., Wan K., Yu C., Celniker S.;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NOMENCLATURE.
RX PubMed=16815999; DOI=10.1101/gad.1426906;
RA Zhang S., Dailey G.M., Kwan E., Glasheen B.M., Sroga G.E., Page-McCaw A.;
RT "An MMP liberates the Ninjurin A ectodomain to signal a loss of cell
RT adhesion.";
RL Genes Dev. 20:1899-1910(2006).
RN [5]
RP FUNCTION.
RX PubMed=33472215; DOI=10.1038/s41586-021-03218-7;
RA Kayagaki N., Kornfeld O.S., Lee B.L., Stowe I.B., O'Rourke K., Li Q.,
RA Sandoval W., Yan D., Kang J., Xu M., Zhang J., Lee W.P., McKenzie B.S.,
RA Ulas G., Payandeh J., Roose-Girma M., Modrusan Z., Reja R., Sagolla M.,
RA Webster J.D., Cho V., Andrews T.D., Morris L.X., Miosge L.A., Goodnow C.C.,
RA Bertram E.M., Dixit V.M.;
RT "NINJ1 mediates plasma membrane rupture during lytic cell death.";
RL Nature 591:131-136(2021).
CC -!- FUNCTION: Homophilic transmembrane adhesion molecule that mediates cell
CC adhesion (By similarity). Able to mediate plasma membrane rupture
CC (cytolysis), leading to release intracellular molecules that propagate
CC the inflammatory response (PubMed:33472215).
CC {ECO:0000250|UniProtKB:Q8MPP0, ECO:0000269|PubMed:33472215}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the ninjurin family. {ECO:0000305}.
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DR EMBL; AE014296; AAF49218.1; -; Genomic_DNA.
DR EMBL; BT022578; AAY54994.1; -; mRNA.
DR EMBL; BT022514; AAY54930.1; -; mRNA.
DR EMBL; BT022541; AAY54957.1; -; mRNA.
DR RefSeq; NP_649068.1; NM_140811.2.
DR AlphaFoldDB; Q9VVT9; -.
DR SMR; Q9VVT9; -.
DR PaxDb; Q9VVT9; -.
DR EnsemblMetazoa; FBtr0075065; FBpp0074832; FBgn0036822.
DR GeneID; 40057; -.
DR KEGG; dme:Dmel_CG11637; -.
DR UCSC; CG11637-RA; d. melanogaster.
DR CTD; 40057; -.
DR FlyBase; FBgn0036822; NijB.
DR VEuPathDB; VectorBase:FBgn0036822; -.
DR eggNOG; ENOG502T8F5; Eukaryota.
DR HOGENOM; CLU_100002_0_0_1; -.
DR InParanoid; Q9VVT9; -.
DR OMA; NYMRTNE; -.
DR OrthoDB; 1560683at2759; -.
DR PhylomeDB; Q9VVT9; -.
DR BioGRID-ORCS; 40057; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 40057; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0036822; Expressed in embryonic/larval hemocyte (Drosophila) and 3 other tissues.
DR ExpressionAtlas; Q9VVT9; differential.
DR Genevisible; Q9VVT9; DM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0019835; P:cytolysis; IDA:UniProtKB.
DR GO; GO:0042246; P:tissue regeneration; IEA:InterPro.
DR InterPro; IPR007007; Ninjurin.
DR PANTHER; PTHR12316; PTHR12316; 1.
DR Pfam; PF04923; Ninjurin; 1.
PE 2: Evidence at transcript level;
KW Cell adhesion; Cytolysis; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..181
FT /note="Ninjurin-B"
FT /id="PRO_0000452830"
FT TOPO_DOM 1..115
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 137..153
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 175..181
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT REGION 1..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..68
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 181 AA; 19930 MW; 9E8A55DCDB6B731A CRC64;
MDSGEVKISL EDSPSSGESF ASTTSGPCCG SGRDLDIQVH ESHIKDDQFP SRATSELQES
KKSNKKCSSD LSTENSYAAN KNVAEGLMDI ALLSANANQL RFLITYNDKA STYIYSMIMV
ILSLVLQLLV GIMLIFKRRL KRFRNRSYER TNDLLVMGVF MITVINILLA AFTTTDGGGS
H
