ID   NIKB_STAA3              Reviewed;         328 AA.
AC   Q2FH55;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Nickel import system permease protein NikB {ECO:0000250|UniProtKB:Q2FYQ5};
GN   Name=nikB {ECO:0000250|UniProtKB:Q2FYQ5}; Synonyms=oppB2;
GN   OrderedLocusNames=SAUSA300_1276;
OS   Staphylococcus aureus (strain USA300).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=367830;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USA300;
RX   PubMed=16517273; DOI=10.1016/s0140-6736(06)68231-7;
RA   Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA   Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA   Perdreau-Remington F.;
RT   "Complete genome sequence of USA300, an epidemic clone of community-
RT   acquired meticillin-resistant Staphylococcus aureus.";
RL   Lancet 367:731-739(2006).
CC   -!- FUNCTION: Part of the ABC transporter complex NikABCDE (Opp2) involved
CC       in nickel import. Probably responsible for the translocation of the
CC       substrate across the membrane. {ECO:0000250|UniProtKB:Q2FYQ5}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (NikD and
CC       NikE), two transmembrane proteins (NikB and NikC) and a solute-binding
CC       protein (NikA). {ECO:0000250|UniProtKB:Q2FYQ5}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. OppBC subfamily. {ECO:0000305}.
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DR   EMBL; CP000255; ABD20380.1; -; Genomic_DNA.
DR   RefSeq; WP_000469949.1; NZ_CP027476.1.
DR   AlphaFoldDB; Q2FH55; -.
DR   SMR; Q2FH55; -.
DR   EnsemblBacteria; ABD20380; ABD20380; SAUSA300_1276.
DR   KEGG; saa:SAUSA300_1276; -.
DR   HOGENOM; CLU_036879_0_2_9; -.
DR   OMA; WPGMGTF; -.
DR   Proteomes; UP000001939; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015675; P:nickel cation transport; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   CDD; cd06261; TM_PBP2; 1.
DR   Gene3D; 1.10.3720.10; -; 1.
DR   InterPro; IPR045621; BPD_transp_1_N.
DR   InterPro; IPR000515; MetI-like.
DR   InterPro; IPR035906; MetI-like_sf.
DR   Pfam; PF00528; BPD_transp_1; 1.
DR   Pfam; PF19300; BPD_transp_1_N; 1.
DR   SUPFAM; SSF161098; SSF161098; 1.
DR   PROSITE; PS50928; ABC_TM1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Nickel; Nickel transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..328
FT                   /note="Nickel import system permease protein NikB"
FT                   /id="PRO_0000276781"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        229..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        279..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   DOMAIN          100..297
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ   SEQUENCE   328 AA;  36814 MW;  DF28C17B1DB7D871 CRC64;
     MFIIKSMLYR LMQMIVVLFV ISTLTFILMK LSPGNPVDKI LHLDVAQVST EQINATKDKL
     GLNDSLLVQW WHWMNHLLHF NLGKSFESKE PVTQILFNYA PITLLISFST LVVSLCISIP
     LGIIAAKRFH KWTDKVIRVI STLSISLPAF FIGIILLFIV TNLMNIDSVI LSQFILPVIT
     LSLGMCAYII RLVRSNLLML LQSNIVQASR LRGMNERYIL IHDLLKPTIL PIIPLLGISL
     GSLIGGTVVI ENLFDIPGIG YLLMDSIKSR DYPVIQGCVL FIGFFVVIIN TIADLLTLLL
     DPKQRLQLGN PKIKTNTPLI SESSDRHA