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NIKB_STAAB
ID   NIKB_STAAB              Reviewed;         328 AA.
AC   Q2YXY7;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Nickel import system permease protein NikB {ECO:0000250|UniProtKB:Q2FYQ5};
GN   Name=nikB {ECO:0000250|UniProtKB:Q2FYQ5}; Synonyms=oppB2;
GN   OrderedLocusNames=SAB1237c;
OS   Staphylococcus aureus (strain bovine RF122 / ET3-1).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=273036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=bovine RF122 / ET3-1;
RX   PubMed=17971880; DOI=10.1371/journal.pone.0001120;
RA   Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.;
RT   "Molecular correlates of host specialization in Staphylococcus aureus.";
RL   PLoS ONE 2:E1120-E1120(2007).
CC   -!- FUNCTION: Part of the ABC transporter complex NikABCDE (Opp2) involved
CC       in nickel import. Probably responsible for the translocation of the
CC       substrate across the membrane. {ECO:0000250|UniProtKB:Q2FYQ5}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (NikD and
CC       NikE), two transmembrane proteins (NikB and NikC) and a solute-binding
CC       protein (NikA). {ECO:0000250|UniProtKB:Q2FYQ5}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. OppBC subfamily. {ECO:0000305}.
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DR   EMBL; AJ938182; CAI80926.1; -; Genomic_DNA.
DR   RefSeq; WP_000469942.1; NC_007622.1.
DR   AlphaFoldDB; Q2YXY7; -.
DR   SMR; Q2YXY7; -.
DR   KEGG; sab:SAB1237c; -.
DR   HOGENOM; CLU_036879_0_2_9; -.
DR   OMA; WPGMGTF; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015675; P:nickel cation transport; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   CDD; cd06261; TM_PBP2; 1.
DR   Gene3D; 1.10.3720.10; -; 1.
DR   InterPro; IPR045621; BPD_transp_1_N.
DR   InterPro; IPR000515; MetI-like.
DR   InterPro; IPR035906; MetI-like_sf.
DR   Pfam; PF00528; BPD_transp_1; 1.
DR   Pfam; PF19300; BPD_transp_1_N; 1.
DR   SUPFAM; SSF161098; SSF161098; 1.
DR   PROSITE; PS50928; ABC_TM1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Nickel; Nickel transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..328
FT                   /note="Nickel import system permease protein NikB"
FT                   /id="PRO_0000276774"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        229..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        279..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   DOMAIN          100..297
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ   SEQUENCE   328 AA;  36715 MW;  6E2A3E2D2FC60811 CRC64;
     MFIIKSMLYR LMQMIVVLFV ISTLTFILMK LSPGNPVDKI LHLDVAQVSM EQINATKDKL
     GLNDSLLVQW WHWMNHLLHF NLGKSFESKE PVTQILFNYA PITLLISFST LVLSLCISIP
     LGIIAAKRFH KLSDKVIRVI STLSISLPAF FIGIILLFIV TNLMNIDSVI LSQFILPVIT
     LSLGMCAYII RLVRSNLLML LQSNIVQASR LRGMNERYIL IHDLLKPTIL PIIPLLGISL
     GSLIGGTVVI ENLFDIPGIG YLLMDSIKSR DYPVIQGCVL FIGFFVVIIN TIADLLTLLL
     DPKQRLQLGN PKSKANTPLI SESSDRHA
 
 
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