NIKB_STAAB
ID NIKB_STAAB Reviewed; 328 AA.
AC Q2YXY7;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Nickel import system permease protein NikB {ECO:0000250|UniProtKB:Q2FYQ5};
GN Name=nikB {ECO:0000250|UniProtKB:Q2FYQ5}; Synonyms=oppB2;
GN OrderedLocusNames=SAB1237c;
OS Staphylococcus aureus (strain bovine RF122 / ET3-1).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=273036;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bovine RF122 / ET3-1;
RX PubMed=17971880; DOI=10.1371/journal.pone.0001120;
RA Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.;
RT "Molecular correlates of host specialization in Staphylococcus aureus.";
RL PLoS ONE 2:E1120-E1120(2007).
CC -!- FUNCTION: Part of the ABC transporter complex NikABCDE (Opp2) involved
CC in nickel import. Probably responsible for the translocation of the
CC substrate across the membrane. {ECO:0000250|UniProtKB:Q2FYQ5}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (NikD and
CC NikE), two transmembrane proteins (NikB and NikC) and a solute-binding
CC protein (NikA). {ECO:0000250|UniProtKB:Q2FYQ5}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. OppBC subfamily. {ECO:0000305}.
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DR EMBL; AJ938182; CAI80926.1; -; Genomic_DNA.
DR RefSeq; WP_000469942.1; NC_007622.1.
DR AlphaFoldDB; Q2YXY7; -.
DR SMR; Q2YXY7; -.
DR KEGG; sab:SAB1237c; -.
DR HOGENOM; CLU_036879_0_2_9; -.
DR OMA; WPGMGTF; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015675; P:nickel cation transport; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; -; 1.
DR InterPro; IPR045621; BPD_transp_1_N.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR Pfam; PF00528; BPD_transp_1; 1.
DR Pfam; PF19300; BPD_transp_1_N; 1.
DR SUPFAM; SSF161098; SSF161098; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 3: Inferred from homology;
KW Cell membrane; Ion transport; Membrane; Nickel; Nickel transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..328
FT /note="Nickel import system permease protein NikB"
FT /id="PRO_0000276774"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 100..297
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ SEQUENCE 328 AA; 36715 MW; 6E2A3E2D2FC60811 CRC64;
MFIIKSMLYR LMQMIVVLFV ISTLTFILMK LSPGNPVDKI LHLDVAQVSM EQINATKDKL
GLNDSLLVQW WHWMNHLLHF NLGKSFESKE PVTQILFNYA PITLLISFST LVLSLCISIP
LGIIAAKRFH KLSDKVIRVI STLSISLPAF FIGIILLFIV TNLMNIDSVI LSQFILPVIT
LSLGMCAYII RLVRSNLLML LQSNIVQASR LRGMNERYIL IHDLLKPTIL PIIPLLGISL
GSLIGGTVVI ENLFDIPGIG YLLMDSIKSR DYPVIQGCVL FIGFFVVIIN TIADLLTLLL
DPKQRLQLGN PKSKANTPLI SESSDRHA