NIKC_STAAM
ID NIKC_STAAM Reviewed; 276 AA.
AC Q99UA1;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Nickel import system permease protein NikC {ECO:0000250|UniProtKB:Q2FYQ6};
GN Name=nikC {ECO:0000250|UniProtKB:Q2FYQ6}; Synonyms=oppC2;
GN OrderedLocusNames=SAV1381;
OS Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=158878;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mu50 / ATCC 700699;
RX PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA Hiramatsu K.;
RT "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL Lancet 357:1225-1240(2001).
CC -!- FUNCTION: Part of the ABC transporter complex NikABCDE (Opp2) involved
CC in nickel import. Probably responsible for the translocation of the
CC substrate across the membrane. {ECO:0000250|UniProtKB:Q2FYQ6}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (NikD and
CC NikE), two transmembrane proteins (NikB and NikC) and a solute-binding
CC protein (NikA). {ECO:0000250|UniProtKB:Q2FYQ6}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. OppBC subfamily. {ECO:0000305}.
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DR EMBL; BA000017; BAB57543.1; -; Genomic_DNA.
DR RefSeq; WP_000548936.1; NC_002758.2.
DR AlphaFoldDB; Q99UA1; -.
DR PaxDb; Q99UA1; -.
DR EnsemblBacteria; BAB57543; BAB57543; SAV1381.
DR KEGG; sav:SAV1381; -.
DR HOGENOM; CLU_028518_5_3_9; -.
DR OMA; VPTYFRM; -.
DR PhylomeDB; Q99UA1; -.
DR BioCyc; SAUR158878:SAV_RS07435-MON; -.
DR Proteomes; UP000002481; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015675; P:nickel cation transport; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; -; 1.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR Pfam; PF00528; BPD_transp_1; 1.
DR SUPFAM; SSF161098; SSF161098; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 3: Inferred from homology;
KW Cell membrane; Ion transport; Membrane; Nickel; Nickel transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..276
FT /note="Nickel import system permease protein NikC"
FT /id="PRO_0000276787"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 108..128
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 238..258
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 69..258
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ SEQUENCE 276 AA; 31241 MW; 1594E7518329BBA9 CRC64;
MHKIFSKNNL IFFVFVAFIF VVIVLQFFVS SENATKVNLS QTFEPISWLH LLGTDDYGRD
LFTRIIIGAR STLFVTVLTL IAIVVIGVTL GLFAGYKKGW IERLVLRFID VGLSIPEFII
MIALASFFQP SLWNLVISIT VIKWMNYTRL TRSIVNSEMN KPYIKMAQLF HVPTRTILIR
HLTPKIIPAI IVLMVVDFGK IILYISSLSF IGLGAQPPTP EWGAMLQQGR DFISSHPIML
IAPASVIAIT ILIFNLTGDA LRDRLLKQRG EYDESH