NIKC_STAAW
ID NIKC_STAAW Reviewed; 276 AA.
AC Q7A0Y0;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Nickel import system permease protein NikC {ECO:0000250|UniProtKB:Q2FYQ6};
GN Name=nikC {ECO:0000250|UniProtKB:Q2FYQ6}; Synonyms=oppC2;
GN OrderedLocusNames=MW1269;
OS Staphylococcus aureus (strain MW2).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=196620;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MW2;
RX PubMed=12044378; DOI=10.1016/s0140-6736(02)08713-5;
RA Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y.,
RA Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
RT "Genome and virulence determinants of high virulence community-acquired
RT MRSA.";
RL Lancet 359:1819-1827(2002).
CC -!- FUNCTION: Part of the ABC transporter complex NikABCDE (Opp2) involved
CC in nickel import. Probably responsible for the translocation of the
CC substrate across the membrane. {ECO:0000250|UniProtKB:Q2FYQ6}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (NikD and
CC NikE), two transmembrane proteins (NikB and NikC) and a solute-binding
CC protein (NikA). {ECO:0000250|UniProtKB:Q2FYQ6}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. OppBC subfamily. {ECO:0000305}.
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DR EMBL; BA000033; BAB95134.1; -; Genomic_DNA.
DR RefSeq; WP_000548932.1; NC_003923.1.
DR AlphaFoldDB; Q7A0Y0; -.
DR EnsemblBacteria; BAB95134; BAB95134; BAB95134.
DR KEGG; sam:MW1269; -.
DR HOGENOM; CLU_028518_5_3_9; -.
DR OMA; VPTYFRM; -.
DR Proteomes; UP000000418; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015675; P:nickel cation transport; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; -; 1.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR Pfam; PF00528; BPD_transp_1; 1.
DR SUPFAM; SSF161098; SSF161098; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 3: Inferred from homology;
KW Cell membrane; Ion transport; Membrane; Nickel; Nickel transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..276
FT /note="Nickel import system permease protein NikC"
FT /id="PRO_0000276788"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 108..128
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 238..258
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 69..258
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ SEQUENCE 276 AA; 31255 MW; 0DE81551833549A0 CRC64;
MHKIFSKNNL IFFVFVAFIF VVIVLQFFVS SENATKVNLS QTFEPISWLH LLGTDDYGRD
LFTRIIIGAR STLFVTVLTL IAIVVIGVTL GLFAGYKKGW IERLVLRFID VGLSIPEFII
MIALASFFQP SLWNLVISIT LIKWMNYTRL TRSIVNSEMN KPYIKMAQLF HVPTRTILIR
HLTPKIIPAI IVLMVVDFGK IILYISSLSF IGLGAQPPTP EWGAMLQQGR DFISSHPIML
IAPASVIAIT ILIFNLTGDA LRDRLLKQRG EYDESH