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NIKC_STAAW
ID   NIKC_STAAW              Reviewed;         276 AA.
AC   Q7A0Y0;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Nickel import system permease protein NikC {ECO:0000250|UniProtKB:Q2FYQ6};
GN   Name=nikC {ECO:0000250|UniProtKB:Q2FYQ6}; Synonyms=oppC2;
GN   OrderedLocusNames=MW1269;
OS   Staphylococcus aureus (strain MW2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=196620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MW2;
RX   PubMed=12044378; DOI=10.1016/s0140-6736(02)08713-5;
RA   Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y.,
RA   Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
RT   "Genome and virulence determinants of high virulence community-acquired
RT   MRSA.";
RL   Lancet 359:1819-1827(2002).
CC   -!- FUNCTION: Part of the ABC transporter complex NikABCDE (Opp2) involved
CC       in nickel import. Probably responsible for the translocation of the
CC       substrate across the membrane. {ECO:0000250|UniProtKB:Q2FYQ6}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (NikD and
CC       NikE), two transmembrane proteins (NikB and NikC) and a solute-binding
CC       protein (NikA). {ECO:0000250|UniProtKB:Q2FYQ6}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. OppBC subfamily. {ECO:0000305}.
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DR   EMBL; BA000033; BAB95134.1; -; Genomic_DNA.
DR   RefSeq; WP_000548932.1; NC_003923.1.
DR   AlphaFoldDB; Q7A0Y0; -.
DR   EnsemblBacteria; BAB95134; BAB95134; BAB95134.
DR   KEGG; sam:MW1269; -.
DR   HOGENOM; CLU_028518_5_3_9; -.
DR   OMA; VPTYFRM; -.
DR   Proteomes; UP000000418; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015675; P:nickel cation transport; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   CDD; cd06261; TM_PBP2; 1.
DR   Gene3D; 1.10.3720.10; -; 1.
DR   InterPro; IPR000515; MetI-like.
DR   InterPro; IPR035906; MetI-like_sf.
DR   Pfam; PF00528; BPD_transp_1; 1.
DR   SUPFAM; SSF161098; SSF161098; 1.
DR   PROSITE; PS50928; ABC_TM1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Nickel; Nickel transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..276
FT                   /note="Nickel import system permease protein NikC"
FT                   /id="PRO_0000276788"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        186..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        238..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   DOMAIN          69..258
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ   SEQUENCE   276 AA;  31255 MW;  0DE81551833549A0 CRC64;
     MHKIFSKNNL IFFVFVAFIF VVIVLQFFVS SENATKVNLS QTFEPISWLH LLGTDDYGRD
     LFTRIIIGAR STLFVTVLTL IAIVVIGVTL GLFAGYKKGW IERLVLRFID VGLSIPEFII
     MIALASFFQP SLWNLVISIT LIKWMNYTRL TRSIVNSEMN KPYIKMAQLF HVPTRTILIR
     HLTPKIIPAI IVLMVVDFGK IILYISSLSF IGLGAQPPTP EWGAMLQQGR DFISSHPIML
     IAPASVIAIT ILIFNLTGDA LRDRLLKQRG EYDESH
 
 
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