NIKD_BRUME
ID NIKD_BRUME Reviewed; 262 AA.
AC Q8YCN8;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Nickel import ATP-binding protein NikD {ECO:0000255|HAMAP-Rule:MF_01711};
DE EC=7.2.2.11 {ECO:0000255|HAMAP-Rule:MF_01711};
GN Name=nikD {ECO:0000255|HAMAP-Rule:MF_01711}; OrderedLocusNames=BMEII0490;
OS Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX NCBI_TaxID=224914;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=16M / ATCC 23456 / NCTC 10094;
RX PubMed=11756688; DOI=10.1073/pnas.221575398;
RA DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T.,
RA Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G.,
RA Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E.,
RA Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J.,
RA Haselkorn R., Kyrpides N.C., Overbeek R.;
RT "The genome sequence of the facultative intracellular pathogen Brucella
RT melitensis.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
CC -!- FUNCTION: Part of the ABC transporter complex NikABCDE involved in
CC nickel import. Responsible for energy coupling to the transport system.
CC {ECO:0000255|HAMAP-Rule:MF_01711}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + Ni(2+)(out) = ADP + H(+) + Ni(2+)(in) + phosphate;
CC Xref=Rhea:RHEA:15557, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:49786,
CC ChEBI:CHEBI:456216; EC=7.2.2.11; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01711};
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (NikD and
CC NikE), two transmembrane proteins (NikB and NikC) and a solute-binding
CC protein (NikA). {ECO:0000255|HAMAP-Rule:MF_01711}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01711}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01711}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Nickel importer
CC (TC 3.A.1.5.3) family. {ECO:0000255|HAMAP-Rule:MF_01711}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE008918; AAL53732.1; -; Genomic_DNA.
DR PIR; AI3570; AI3570.
DR RefSeq; WP_002965841.1; NZ_GG703779.1.
DR AlphaFoldDB; Q8YCN8; -.
DR SMR; Q8YCN8; -.
DR STRING; 224914.BMEII0490; -.
DR EnsemblBacteria; AAL53732; AAL53732; BMEII0490.
DR GeneID; 3827146; -.
DR KEGG; bme:BMEII0490; -.
DR PATRIC; fig|224914.52.peg.2882; -.
DR eggNOG; COG0444; Bacteria.
DR OMA; AFIMQNP; -.
DR PhylomeDB; Q8YCN8; -.
DR Proteomes; UP000000419; Chromosome II.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015413; F:ABC-type nickel transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR014138; Nickel_NikD.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR02770; nickel_nikD; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS51247; NIKD; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW Nickel; Nickel transport; Nucleotide-binding; Translocase; Transport.
FT CHAIN 1..262
FT /note="Nickel import ATP-binding protein NikD"
FT /id="PRO_0000092618"
FT DOMAIN 6..249
FT /note="ABC transporter"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01711"
FT BINDING 42..49
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01711"
SQ SEQUENCE 262 AA; 28251 MW; 773F874C645C344B CRC64;
MTRKTLAIEG LTATTVIDGQ QRVLVDNLSL GVQRGRILAL VGASGSGKSM TCSAALGVLP
PGVTASRGRV TIDGVPYAAN ALRGRHVATI MQNPRSAFNP VRTMRDHAIE TLQALGKLSS
NPQDQIVHCM RAAGLEDVKT ILSLHPFEMS GGMLQRMMIA LALLSEAPFL FADEPTTDLD
LVVQLRVLEL LEKLVEERDL GILLVTHDMG VVARLAHDVA VLDHGRLIEQ APVMDIFQTP
GHEVTRMLVS AHLSLYGMEL NA