NIKD_BRUSU
ID NIKD_BRUSU Reviewed; 262 AA.
AC Q8FVM9; G0KDG7; Q9AL79;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Nickel import ATP-binding protein NikD {ECO:0000255|HAMAP-Rule:MF_01711};
DE EC=7.2.2.11 {ECO:0000255|HAMAP-Rule:MF_01711};
GN Name=nikD {ECO:0000255|HAMAP-Rule:MF_01711};
GN OrderedLocusNames=BRA0801, BS1330_II0794;
OS Brucella suis biovar 1 (strain 1330).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX NCBI_TaxID=204722;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND INDUCTION.
RC STRAIN=1330;
RX PubMed=11133934; DOI=10.1128/jb.183.2.426-434.2001;
RA Jubier-Maurin V., Rodrigue A., Ouahrani-Bettache S., Layssac M.,
RA Mandrand-Berthelot M.-A., Koehler S., Liautard J.-P.;
RT "Identification of the nik gene cluster of Brucella suis: regulation and
RT contribution to urease activity.";
RL J. Bacteriol. 183:426-434(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1330;
RX PubMed=12271122; DOI=10.1073/pnas.192319099;
RA Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F.,
RA Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J.,
RA Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R.,
RA Nelson W.C., Ayodeji B., Kraul M., Shetty J., Malek J.A., Van Aken S.E.,
RA Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L.,
RA Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.;
RT "The Brucella suis genome reveals fundamental similarities between animal
RT and plant pathogens and symbionts.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1330;
RX PubMed=22038969; DOI=10.1128/jb.06181-11;
RA Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.;
RT "Revised genome sequence of Brucella suis 1330.";
RL J. Bacteriol. 193:6410-6410(2011).
CC -!- FUNCTION: Part of the ABC transporter complex NikABCDE involved in
CC nickel import. Responsible for energy coupling to the transport system.
CC {ECO:0000255|HAMAP-Rule:MF_01711}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + Ni(2+)(out) = ADP + H(+) + Ni(2+)(in) + phosphate;
CC Xref=Rhea:RHEA:15557, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:49786,
CC ChEBI:CHEBI:456216; EC=7.2.2.11; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01711};
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (NikD and
CC NikE), two transmembrane proteins (NikB and NikC) and a solute-binding
CC protein (NikA). {ECO:0000255|HAMAP-Rule:MF_01711}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01711}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01711}.
CC -!- INDUCTION: Induced by low oxygen tension and metal ion deficiency.
CC Repressed by NiCl(2) excess. {ECO:0000269|PubMed:11133934}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Nickel importer
CC (TC 3.A.1.5.3) family. {ECO:0000255|HAMAP-Rule:MF_01711}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAC24696.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AJ278644; CAC24696.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE014292; AAN33979.1; -; Genomic_DNA.
DR EMBL; CP002998; AEM20255.1; -; Genomic_DNA.
DR RefSeq; WP_004690304.1; NZ_KN046805.1.
DR AlphaFoldDB; Q8FVM9; -.
DR SMR; Q8FVM9; -.
DR EnsemblBacteria; AEM20255; AEM20255; BS1330_II0794.
DR GeneID; 45053816; -.
DR GeneID; 55592450; -.
DR KEGG; bms:BRA0801; -.
DR KEGG; bsi:BS1330_II0794; -.
DR PATRIC; fig|204722.21.peg.3646; -.
DR HOGENOM; CLU_000604_1_23_5; -.
DR OMA; AFIMQNP; -.
DR PhylomeDB; Q8FVM9; -.
DR Proteomes; UP000007104; Chromosome II.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015413; F:ABC-type nickel transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR014138; Nickel_NikD.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR02770; nickel_nikD; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS51247; NIKD; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW Nickel; Nickel transport; Nucleotide-binding; Translocase; Transport.
FT CHAIN 1..262
FT /note="Nickel import ATP-binding protein NikD"
FT /id="PRO_0000092619"
FT DOMAIN 6..249
FT /note="ABC transporter"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01711"
FT BINDING 42..49
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01711"
SQ SEQUENCE 262 AA; 28221 MW; B91C0248740D7D03 CRC64;
MTRKTLAIEG LTATTVIDGQ QRVLVDNLSL GVQRGRILAL VGASGSGKSM TCSAALGVLP
PGVTASRGRV TIDGVPYAAN ALRGRHVATI MQNPRGAFNP VRTMRDHAIE TLQALGKLSS
NPQDQIVHCM RAAGLEDVKT ILSLHPFEMS GGMLQRMMIA LALLSEAPFL FADEPTTDLD
LVVQLRVLEL LEKLVEERDL GILLVTHDMG VVARLAHDVA VLDHGRLIEQ APVMDIFQTP
GHEVTRMLVS AHLSLYGMEL NA
