NIKD_ECO57
ID NIKD_ECO57 Reviewed; 254 AA.
AC Q8X5U1; Q7AA45;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Nickel import ATP-binding protein NikD {ECO:0000255|HAMAP-Rule:MF_01711};
DE EC=7.2.2.11 {ECO:0000255|HAMAP-Rule:MF_01711};
GN Name=nikD {ECO:0000255|HAMAP-Rule:MF_01711};
GN OrderedLocusNames=Z4871, ECs4346;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
CC -!- FUNCTION: Part of the ABC transporter complex NikABCDE involved in
CC nickel import. Responsible for energy coupling to the transport system.
CC {ECO:0000255|HAMAP-Rule:MF_01711}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + Ni(2+)(out) = ADP + H(+) + Ni(2+)(in) + phosphate;
CC Xref=Rhea:RHEA:15557, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:49786,
CC ChEBI:CHEBI:456216; EC=7.2.2.11; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01711};
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (NikD and
CC NikE), two transmembrane proteins (NikB and NikC) and a solute-binding
CC protein (NikA). {ECO:0000255|HAMAP-Rule:MF_01711}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01711}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01711}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Nickel importer
CC (TC 3.A.1.5.3) family. {ECO:0000255|HAMAP-Rule:MF_01711}.
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DR EMBL; AE005174; AAG58606.1; -; Genomic_DNA.
DR EMBL; BA000007; BAB37769.1; -; Genomic_DNA.
DR PIR; B86018; B86018.
DR PIR; B91172; B91172.
DR RefSeq; NP_312373.1; NC_002695.1.
DR RefSeq; WP_001136210.1; NZ_SWKA01000005.1.
DR AlphaFoldDB; Q8X5U1; -.
DR SMR; Q8X5U1; -.
DR STRING; 155864.EDL933_4710; -.
DR EnsemblBacteria; AAG58606; AAG58606; Z4871.
DR EnsemblBacteria; BAB37769; BAB37769; ECs_4346.
DR GeneID; 915804; -.
DR KEGG; ece:Z4871; -.
DR KEGG; ecs:ECs_4346; -.
DR PATRIC; fig|386585.9.peg.4539; -.
DR eggNOG; COG0444; Bacteria.
DR HOGENOM; CLU_000604_1_23_6; -.
DR OMA; HDIRMVA; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015413; F:ABC-type nickel transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR014138; Nickel_NikD.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR02770; nickel_nikD; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS51247; NIKD; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW Nickel; Nickel transport; Nucleotide-binding; Reference proteome;
KW Translocase; Transport.
FT CHAIN 1..254
FT /note="Nickel import ATP-binding protein NikD"
FT /id="PRO_0000092622"
FT DOMAIN 2..241
FT /note="ABC transporter"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01711"
FT BINDING 36..43
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01711"
SQ SEQUENCE 254 AA; 26790 MW; CB5CE59E1E974AF4 CRC64;
MPQQIELRNI ALQAAQPLVH GVSLTLKRGR VLALVGGSGS GKSLTCAATL GILPAGVRQT
AGEILADGKP VSPCALRGIK IATIMQNPRS AFNPLHTMHT HARETCLALG KPADDATLTA
AIEAVGLENA ARVLKLYPFE MSGGMLQRMM IAMAVLCESP FIIADEPTTD LDVVAQARIL
DLLESIMQKQ APGMLLVTHD MGVVARLADD VAVMSDGKIV EQGDVETLFN APKHAVTRSL
VSAHLALYGM ELAS
