ID   NIKD_ECOL6              Reviewed;         254 AA.
AC   Q8FCN0;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Nickel import ATP-binding protein NikD {ECO:0000255|HAMAP-Rule:MF_01711};
DE            EC=7.2.2.11 {ECO:0000255|HAMAP-Rule:MF_01711};
GN   Name=nikD {ECO:0000255|HAMAP-Rule:MF_01711}; OrderedLocusNames=c4272;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Part of the ABC transporter complex NikABCDE involved in
CC       nickel import. Responsible for energy coupling to the transport system.
CC       {ECO:0000255|HAMAP-Rule:MF_01711}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + Ni(2+)(out) = ADP + H(+) + Ni(2+)(in) + phosphate;
CC         Xref=Rhea:RHEA:15557, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:49786,
CC         ChEBI:CHEBI:456216; EC=7.2.2.11; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01711};
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (NikD and
CC       NikE), two transmembrane proteins (NikB and NikC) and a solute-binding
CC       protein (NikA). {ECO:0000255|HAMAP-Rule:MF_01711}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01711}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01711}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. Nickel importer
CC       (TC 3.A.1.5.3) family. {ECO:0000255|HAMAP-Rule:MF_01711}.
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DR   EMBL; AE014075; AAN82708.1; -; Genomic_DNA.
DR   RefSeq; WP_001136233.1; NC_004431.1.
DR   AlphaFoldDB; Q8FCN0; -.
DR   SMR; Q8FCN0; -.
DR   STRING; 199310.c4272; -.
DR   EnsemblBacteria; AAN82708; AAN82708; c4272.
DR   KEGG; ecc:c4272; -.
DR   eggNOG; COG0444; Bacteria.
DR   HOGENOM; CLU_000604_1_23_6; -.
DR   OMA; AFIMQNP; -.
DR   BioCyc; ECOL199310:C4272-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015413; F:ABC-type nickel transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR014138; Nickel_NikD.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR02770; nickel_nikD; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR   PROSITE; PS51247; NIKD; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Nickel; Nickel transport; Nucleotide-binding; Translocase; Transport.
FT   CHAIN           1..254
FT                   /note="Nickel import ATP-binding protein NikD"
FT                   /id="PRO_0000092621"
FT   DOMAIN          2..241
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01711"
FT   BINDING         36..43
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01711"
SQ   SEQUENCE   254 AA;  26840 MW;  B4CFC5197A4BA675 CRC64;
     MPQQIELRNI ALQAAQPLVH GVSLTLQRGR VLALVGGSGS GKSLTCAATL GILPAGVRQT
     AGEILADGKP VSPCALRGIK IATIMQNPRS AFNPLHTMHT HARETCLALG KPADDATLTA
     AIEAVGLENA ARVLKLYPFE MSGGMLQRMM IAMAVLCESP FIIADEPTTD LDVVAQARIL
     DLLESIMQKQ APGMLLVTHD MGVVARLADD VAVMSHGKIV EQGDVETLFN VPKHAVTRSL
     VSAHLALYGM ELAS