ID   NIKD_ECOUT              Reviewed;         254 AA.
AC   Q1R5D9;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Nickel import ATP-binding protein NikD {ECO:0000255|HAMAP-Rule:MF_01711};
DE            EC=7.2.2.11 {ECO:0000255|HAMAP-Rule:MF_01711};
GN   Name=nikD {ECO:0000255|HAMAP-Rule:MF_01711}; OrderedLocusNames=UTI89_C3996;
OS   Escherichia coli (strain UTI89 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=364106;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UTI89 / UPEC;
RX   PubMed=16585510; DOI=10.1073/pnas.0600938103;
RA   Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A.,
RA   Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S.,
RA   Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J.,
RA   Gordon J.I.;
RT   "Identification of genes subject to positive selection in uropathogenic
RT   strains of Escherichia coli: a comparative genomics approach.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:5977-5982(2006).
CC   -!- FUNCTION: Part of the ABC transporter complex NikABCDE involved in
CC       nickel import. Responsible for energy coupling to the transport system.
CC       {ECO:0000255|HAMAP-Rule:MF_01711}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + Ni(2+)(out) = ADP + H(+) + Ni(2+)(in) + phosphate;
CC         Xref=Rhea:RHEA:15557, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:49786,
CC         ChEBI:CHEBI:456216; EC=7.2.2.11; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_01711};
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (NikD and
CC       NikE), two transmembrane proteins (NikB and NikC) and a solute-binding
CC       protein (NikA). {ECO:0000255|HAMAP-Rule:MF_01711}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01711}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01711}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. Nickel importer
CC       (TC 3.A.1.5.3) family. {ECO:0000255|HAMAP-Rule:MF_01711}.
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DR   EMBL; CP000243; ABE09425.1; -; Genomic_DNA.
DR   RefSeq; WP_001136232.1; NC_007946.1.
DR   AlphaFoldDB; Q1R5D9; -.
DR   SMR; Q1R5D9; -.
DR   EnsemblBacteria; ABE09425; ABE09425; UTI89_C3996.
DR   KEGG; eci:UTI89_C3996; -.
DR   HOGENOM; CLU_000604_1_23_6; -.
DR   OMA; AFIMQNP; -.
DR   Proteomes; UP000001952; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015413; F:ABC-type nickel transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR014138; Nickel_NikD.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR02770; nickel_nikD; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR   PROSITE; PS51247; NIKD; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Nickel; Nickel transport; Nucleotide-binding; Translocase; Transport.
FT   CHAIN           1..254
FT                   /note="Nickel import ATP-binding protein NikD"
FT                   /id="PRO_0000274113"
FT   DOMAIN          2..241
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01711"
FT   BINDING         36..43
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01711"
SQ   SEQUENCE   254 AA;  26812 MW;  45A8C5197A4BA66D CRC64;
     MPQQIELRNI ALQAAQPLVH GVSLTLQRGR VLALVGGSGS GKSLTCAATL GILPAGVRQT
     AGEILADGKP VSPCALRGIK IATIMQNPRS AFNPLHTMHT HARETCLALG KPADDATLTA
     AIEAVGLENA ARVLKLYPFE MSGGMLQRMM IAMAVLCESP FIIADEPTTD LDVVAQARIL
     DLLESIMQKQ APGMLLVTHD MGVVARLADD VAVMSHGKIV EQGDVETLFN APKHAVTRSL
     VSAHLALYGM ELAS