NIKD_SHIFL
ID NIKD_SHIFL Reviewed; 254 AA.
AC Q83J78; Q7BYV8;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Nickel import ATP-binding protein NikD {ECO:0000255|HAMAP-Rule:MF_01711};
DE EC=7.2.2.11 {ECO:0000255|HAMAP-Rule:MF_01711};
GN Name=nikD {ECO:0000255|HAMAP-Rule:MF_01711};
GN OrderedLocusNames=SF3497, S4266;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Part of the ABC transporter complex NikABCDE involved in
CC nickel import. Responsible for energy coupling to the transport system.
CC {ECO:0000255|HAMAP-Rule:MF_01711}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + Ni(2+)(out) = ADP + H(+) + Ni(2+)(in) + phosphate;
CC Xref=Rhea:RHEA:15557, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:49786,
CC ChEBI:CHEBI:456216; EC=7.2.2.11; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01711};
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (NikD and
CC NikE), two transmembrane proteins (NikB and NikC) and a solute-binding
CC protein (NikA). {ECO:0000255|HAMAP-Rule:MF_01711}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01711}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01711}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Nickel importer
CC (TC 3.A.1.5.3) family. {ECO:0000255|HAMAP-Rule:MF_01711}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE005674; AAN44956.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP19226.1; -; Genomic_DNA.
DR RefSeq; NP_709249.1; NC_004337.2.
DR RefSeq; WP_001136253.1; NZ_WPGW01000010.1.
DR AlphaFoldDB; Q83J78; -.
DR SMR; Q83J78; -.
DR STRING; 198214.SF3497; -.
DR EnsemblBacteria; AAN44956; AAN44956; SF3497.
DR EnsemblBacteria; AAP19226; AAP19226; S4266.
DR GeneID; 1026393; -.
DR KEGG; sfl:SF3497; -.
DR KEGG; sft:NCTC1_03779; -.
DR KEGG; sfx:S4266; -.
DR PATRIC; fig|198214.7.peg.4118; -.
DR HOGENOM; CLU_000604_1_23_6; -.
DR OMA; AFIMQNP; -.
DR OrthoDB; 1101128at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015413; F:ABC-type nickel transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR014138; Nickel_NikD.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR02770; nickel_nikD; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS51247; NIKD; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW Nickel; Nickel transport; Nucleotide-binding; Reference proteome;
KW Translocase; Transport.
FT CHAIN 1..254
FT /note="Nickel import ATP-binding protein NikD"
FT /id="PRO_0000092624"
FT DOMAIN 2..241
FT /note="ABC transporter"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01711"
FT BINDING 36..43
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01711"
SQ SEQUENCE 254 AA; 26923 MW; F6BFC51EAA87CA3A CRC64;
MPQQIELRNI TLQAAQPLVH GVSLTLQRGR VLALVGGSGS GKSLTCAATL GILPAGVRQT
AGEILADGKP VSPYALRGIK IATIMQNPRS AFNPLHTMHT HARETCLALG KPADDATLTA
AIEAVGLENA ARVLKLYPFE MSGGMLQRMM IAMAVLCESP FIIADEPTTD LDVVAQARIL
DLLESIMQKQ APGMLLVTHD MGVVARLADD VAVMSQGKIV EQGDVETLFN APKHTVTRSL
VSAHLALYGM ELAS
