NIKD_STAA3
ID NIKD_STAA3 Reviewed; 257 AA.
AC Q2FH57;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Nickel import system ATP-binding protein NikD {ECO:0000250|UniProtKB:Q2FYQ7};
DE EC=7.2.2.11 {ECO:0000250|UniProtKB:Q2FYQ7};
GN Name=nikD {ECO:0000250|UniProtKB:Q2FYQ7}; Synonyms=oppD2;
GN OrderedLocusNames=SAUSA300_1274;
OS Staphylococcus aureus (strain USA300).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=367830;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=USA300;
RX PubMed=16517273; DOI=10.1016/s0140-6736(06)68231-7;
RA Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA Perdreau-Remington F.;
RT "Complete genome sequence of USA300, an epidemic clone of community-
RT acquired meticillin-resistant Staphylococcus aureus.";
RL Lancet 367:731-739(2006).
CC -!- FUNCTION: Part of the ABC transporter complex NikABCDE (Opp2) involved
CC in nickel import. Probably responsible for energy coupling to the
CC transport system. {ECO:0000250|UniProtKB:Q2FYQ7}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + Ni(2+)(out) = ADP + H(+) + Ni(2+)(in) + phosphate;
CC Xref=Rhea:RHEA:15557, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:49786,
CC ChEBI:CHEBI:456216; EC=7.2.2.11;
CC Evidence={ECO:0000250|UniProtKB:Q2FYQ7};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15558;
CC Evidence={ECO:0000250|UniProtKB:Q2FYQ7};
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (NikD and
CC NikE), two transmembrane proteins (NikB and NikC) and a solute-binding
CC protein (NikA). {ECO:0000250|UniProtKB:Q2FYQ7}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Peripheral membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR EMBL; CP000255; ABD21491.1; -; Genomic_DNA.
DR RefSeq; WP_000052317.1; NZ_CP027476.1.
DR AlphaFoldDB; Q2FH57; -.
DR SMR; Q2FH57; -.
DR PRIDE; Q2FH57; -.
DR EnsemblBacteria; ABD21491; ABD21491; SAUSA300_1274.
DR KEGG; saa:SAUSA300_1274; -.
DR HOGENOM; CLU_000604_1_23_9; -.
DR OMA; THSFNDH; -.
DR Proteomes; UP000001939; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015413; F:ABC-type nickel transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell membrane; Ion transport; Membrane; Nickel;
KW Nickel transport; Nucleotide-binding; Translocase; Transport.
FT CHAIN 1..257
FT /note="Nickel import system ATP-binding protein NikD"
FT /id="PRO_0000276799"
FT DOMAIN 4..245
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 37..44
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 257 AA; 29549 MW; 9E8B11C357BBE8B1 CRC64;
MSLIDIQNLT IKNTSEKSLI KGIDLKIFSQ QINALIGESG AGKSLIAKAL LEYLPFDLSC
TYDSYQFDGE NVSRLSQYYG HTIGYISQNY AESFNDHTKL GKQLTAIYRK HYKGSKEEAL
SKVDKALSWV NLQSKDILNK YSFQLSGGQL ERVYIASVLM LEPKLIIADE PVASLDALNG
NQVMDLLQHI VLEHGQTLFI ITHNLSHVLK YCQYIYVLKE GQIIERGNIN HFKYEHLHPY
TERLIKYRTQ LKRDYYD
